Table 9

Results of meta-analysis.

Study

FMS

Controls

Weight

SMD


Mean

Std

Total

Mean

Std

Total

IV, Random, 95% CI


IL-1: plasma, ELISA or immunoassay


Togo 2009

0.79

0.64

7

1.24

1.17

9

16.4%

-0.43 [-1.44, 0.57]


Feng 2009

74.5

116.5

100

45.6

53.1

35

41.3%

0.28 [-0.11, 0.66]


Bazzichi 2007

4.54

9.7

80

7.44

6.62

45

42.3%

-0.33 [-0.70, 0.04]


Total (95% CI)

187

89

100.0%

-0.10 [-0.58, 0.39]


Heterogeneity: Tau2 = 0.11; Chi2 = 5.52, df = 2 (P = 0.06); I2 = 64%


Test for overall effect: Z = 0.39 (P = 0.69)


IL-6: plasma, ELISA or immunoassay or bioplex assay


Togo 2009

14.0

10.9

7

16.8

15.3

9

9.6%

-0.19 [-1.19, 0.80]


Schwarz 2002

1.01

0.47

17

1.45

2.17

17

20.7%

-0.27 [-0.95, 0.40]


Bazzichi 2007

2.76

3.99

80

4.34

4.51

45

69.7%

-0.38 [-0.74, -0.01]


Total (95% CI)

104

71

100.0%

-0.34 [-0.64, -0.03]


Heterogeneity: Tau2 = 0.00; Chi2 = 0.15, df = 2 (P = 0.93); I2 = 0%


Test for overall effect: Z = 2.15 (P = 0.03)


IL-6: serum, ELISA or immunoassay or bioplex assay


Gür 2002

5.52

3.96

81

5.46

1.37

32

25.7%

0.02 [-0.39, 0.43]


Hernandez 2010

16.28

8.13

64

0.92

0.32

25

24.8%

2.20 [1.63, 2.77]


Wallace 2001

7.19

2.02

56

6.3

6.72

36

25.6%

0.20 [-0.22, 0.62]


Wang 2008

2.57

1.38

20

0.92

0.32

25

23.9%

1.71 [1.02, 2.40]


Total (95% CI)

221

118

100.0%

1.01 [-0.03, 2.05]


Heterogeneity: Tau2 = 1.05; Chi2 = 51.09, df = 3 (P < 0.00001); I2 = 94%


Test for overall effect: Z = 1.91 (P = 0.06)


IL-8: plasma, ELISA or immunoassay


Bazzichi 2007

61.89

149.0

80

7.9

17.5

45

41.2%

0.45 [0.08, 0.82]


Blanco 2010

83.0

253.0

79

84.0

253.0

59

42.8%

-0.00 [-0.34, 0.33]


Togo 2009

8.4

1.9

7

11.8

5.4

9

16.0%

-0.75 [-1.79, 0.28]


Total (95% CI)

166

113

100.0%

0.06 [-0.43, 0.56]


Heterogeneity: Tau2 = 0.12; Chi2 = 6.23, df = 2 (P = 0.04); I2 = 68%


Test for overall effect: Z = 0.25 (P = 0.80)


TNF: serum, ELISA or immunoassay or bioplex assay


Hernandez 2010

20.42

7.24

64

35.73

0.72

25

33.0%

-2.46 [-3.05, -1.87]


Wang 2008

3.27

5.08

20

3.89

12.95

80

33.5%

-0.05 [-0.54, 0.44]


Üçeyler 2006

7.41

11.01

26

6.7

9.5

40

33.5%

0.07 [-0.42, 0.56]


Total (95% CI)

110

145

100.0%

-0.81 [-2.31, 0.70]


Heterogeneity: Tau2 = 1.70; Chi2 = 49.74, df = 2 (P < 0.00001); I2 = 96%


Test for overall effect: Z = 1.05 (P = 0.29)


TNF: plasma, ELISA or immunoassay


Bazzichi 2007

22.59

29.55

80

11.07

6.77

45

28.0%

0.48 [0.11, 0.85]


Blanco 2010

163.0

435.0

79

161.0

319.0

59

28.5%

0.01 [-0.33, 0.34]


Feng 2009

12.2

10.2

100

40.1

73.5

35

27.6%

-0.73 [-1.12, -0.33]


Togo 2009

0.24

0.13

7

0.7

0.61

9

16.0%

-0.93 [-1.98, 0.13]


Total (95% CI)

266

148

100.0%

-0.21 [-0.82, 0.39]


Heterogeneity: Tau2 = 0.30; Chi2 = 21.71, df = 3 (P < 0.0001); I2 = 86%


Test for overall effect: Z = 0.69 (P = 0.49)


Üçeyler et al. BMC Musculoskeletal Disorders 2011 12:245   doi:10.1186/1471-2474-12-245

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