Table 8

Characteristics of studies investigating levels of cytokines in skin of FMS patients.

Author, yr.

Diagnosis criteria

N patients/controls

a) Material

b) Methods

c) Investigated targets

Results

Modified CEBM

level

NOS

W-MeQS


Salemi, 2003

ACR

53/10

a) skin biopsy

b) RT-PCR, IHC

c) IL-1β, IL-6, TNF

Detectable cytokines in FMS:

IL-1β (19/50)

IL-6 (14/51)

TNF (17/53)

None of the cytokines could be detected in control skin.

3d

2

0.7


Blanco, 2010

ACR

63/49

a) skin

b) IHC

c) MCP-1, TNF

MCP-1: FMS < controls

3c

3

0.8


Abbreviations:

ACR: American College of Rheumatology; CEMB: Center of Evidence Based Medicine; FMS: fibromyalgia syndrome; IHC: immunohistochemistry; IL: interleukin; NOS: Newcastle Ottawa Scale; RT-PCR: reverse transcriptions PCR; W-MeQS: Würzburg Methodological Quality Score; yr: year

Üçeyler et al. BMC Musculoskeletal Disorders 2011 12:245   doi:10.1186/1471-2474-12-245

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