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Anamnestic risk factor questionnaire as reliable diagnostic instrument for osteoporosis (reduced bone morphogenic density)

Leila Kolios1*, Caner Takur2, Arash Moghaddam2, Mirjam Hitzler2, Heinrich Schmidt-Gayk3, Arnold J Suda2, Bernd Höner4, Paul A Grützner2 and Christoph Wölfl2

Author Affiliations

1 Department for Plastic-, Reconstructive and Handsurgery, Burn Care Centre, BG Unfallklinik Ludwigshafen, Ludwig-Guttmann-Str.13, 67071 Ludwigshafen, Germany

2 Department of Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, Ludwig-Guttmann-Str.13, 67071 Ludwigshafen, Germany

3 Clinical Laboratory Limbach, Im Breitspiel 15, 69126 Heidelberg, Germany

4 Department of Social and Legal Sciences, SRH Hochschule Heidelberg, Ludwig-Guttmann-Str.6, 69123 Heidelberg, Germany

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BMC Musculoskeletal Disorders 2011, 12:187  doi:10.1186/1471-2474-12-187

Published: 17 August 2011



Osteoporosis is a major health problem worldwide, and is included in the WHO list of the top 10 major diseases. However, it is often undiagnosed until the first fracture occurs, due to inadequate patient education and lack of insurance coverage for screening tests. Anamnestic risk factors like positive family anamnesis or early menopause are assumed to correlate with reduced BMD.


In our study of 78 patients with metaphyseal long bone fractures, we searched for a correlation between anamnestic risk factors, bone specific laboratory values, and the bone morphogenic density (BMD). Each indicator was examined as a possible diagnostic instrument for osteoporosis. The secondary aim of this study was to demonstrate the high prevalence of osteoporosis in patients with metaphyseal fractures.


76.9% of our fracture patients had decreased bone density and 43.6% showed manifest osteoporosis in DXA (densitometry) measurements. Our questionnaire, identifying anamnestic risk factors, correlated highly significantly (p = 0.01) with reduced BMD, whereas seven bone-specific laboratory values (p = 0.046) correlated significantly.


Anamnestic risk factors correlate with pathological BMD. The medical questionnaire used in this study would therefore function as a cost-effective primary diagnostic instrument for identification of osteoporosis patients.