Table 3 |
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|
Genes differentially expressed in OA meniscal cells compared to normal meniscal cells. |
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|
Biological process |
Gene Name |
Gene ID |
Differ Exp (fold)* |
Description |
|
|
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|
Immune response |
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|
|
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|
HLA-DPA1 |
M27487 |
5.3 |
Major histocompatibility complex, class II, DP alpha 1 |
|
|
|
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|
IFI6 |
2.0 |
Interferon, alpha-inducible protein 6 |
||
|
|
||||
|
CFH |
1.7 |
Complement factor H |
||
|
|
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|
CTSS |
1.6 |
Cathepsin S |
||
|
|
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|
FYN |
S74774 |
1.5 |
FYN oncogene related to SRC, FGR, YES |
|
|
|
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|
ILF2 |
-1.3 |
Interleukin enhancer binding factor 2, 45 kDa |
||
|
|
||||
|
PSMB9 |
-1.2 |
Proteasome (prosome, macropain) subunit, beta type, 9 |
||
|
|
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|
Inflammatory Response |
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|
|
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|
ITGB2 |
6.6 |
Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
||
|
|
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|
CFH |
1.7 |
Complement factor H |
||
|
|
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|
BDKRB2 |
1.3 |
Bradykinin receptor B2 |
||
|
|
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|
Cytokine production |
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|
|
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|
SRGN |
2.8 |
Serglycin |
||
|
|
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|
ARNT |
2.3 |
Aryl hydrocarbon receptor nuclear translocator |
||
|
|
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|
INHBA |
1.9 |
Inhibin, beta A |
||
|
|
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|
Calcium ion transport |
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|
|
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|
CACNA1C |
1.5 |
Calcium channel, voltage-dependent, L type, alpha 1C subunit |
||
|
|
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|
FYN |
1.5 |
FYN oncogene related to SRC, FGR, YES |
||
|
|
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|
CHRNB2 |
1.4 |
Cholinergic receptor, nicotinic, beta 2 (neuronal) |
||
|
|
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|
Biomineral formation |
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|
|
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|
ENPP1 |
1.7 |
Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
||
|
|
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|
SRGN |
2.8 |
Serglycin |
||
|
|
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|
ACVR2A |
1.5 |
Activin A receptor, type IIA |
||
|
|
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|
Cell proliferation |
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|
|
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|
ITGB2 |
6.6 |
Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
||
|
|
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|
FGF7 |
4.1 |
Fibroblast growth factor 7 (keratinocyte growth factor) |
||
|
|
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|
ELN |
2.5 |
Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) |
||
|
|
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|
IGFBP7 |
2.4 |
Insulin-like growth factor binding protein 7 |
||
|
|
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|
SKAP2 |
2.2 |
Src kinase associated phosphoprotein 2 |
||
|
|
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|
ARNT |
2.3 |
Aryl hydrocarbon receptor nuclear translocator |
||
|
|
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|
FOXO1 |
1.5 |
Forkhead box O1 |
||
|
|
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|
BCAT1 |
1.5 |
Branched chain aminotransferase 1, cytosolic |
||
|
|
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|
ACVR2A |
1.5 |
Activin A receptor, type IIA |
||
|
|
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|
TCF7L2 |
1.4 |
Transcription factor 7-like 2 (T-cell specific, HMG-box) |
||
|
|
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|
CHRNB2 |
1.4 |
Cholinergic receptor, nicotinic, beta 2 (neuronal) |
||
|
|
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|
TCFL5 |
1.2 |
Transcription factor-like 5 (basic helix-loop-helix) |
||
|
|
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|
NRP1 |
-1.3 |
Neuropilin 1 |
||
|
|
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|
PHB |
-1.3 |
Prohibitin |
||
|
|
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|
TBX5 |
-1.3 |
T-box 5 |
||
|
|
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|
NCK2 |
-1.2 |
NCK adaptor protein 2 |
||
|
|
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|
PRPF19 |
-1.2 |
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) |
||
|
|
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|
Integrin-mediated signaling pathway |
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|
|
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|
ITGB2 |
6.6 |
Integrin, beta 2 |
||
|
|
||||
|
ITGB8 |
3.6 |
Integrin, beta 8 |
||
|
|
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|
ITGA11 |
1.5 |
integrin, alpha 11 |
||
|
|
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|
GAB2 |
1.5 |
GRB2-associated binding protein 2 |
||
|
|
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|
Skeletal system/Tissue development |
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|
|
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|
DSP |
5.2 |
Desmoplakin |
||
|
|
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|
FGF7 |
4.2 |
Fibroblast growth factor 7 (keratinocyte growth factor) |
||
|
|
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|
SRGN |
2.8 |
Serglycin |
||
|
|
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|
INHBA |
1.9 |
Inhibin, beta A |
||
|
|
||||
|
TIMP3 |
1.7 |
TIMP metallopeptidase inhibitor 3 |
||
|
|
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|
ENPP1 |
1.7 |
Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
||
|
|
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|
COL5A1 |
1.7 |
Collagen, type V, alpha 1 |
||
|
|
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|
ACVR2A |
1.5 |
Activin A receptor, type IIA |
||
|
|
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|
FBN1 |
1.4 |
Fibrillin 1 |
||
|
|
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|
BARX1 |
-1.9 |
BARX homeobox 1 |
||
|
|
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|
GABBR1 |
-1.9 |
Gamma-aminobutyric acid (GABA) B receptor, 1 |
||
|
|
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|
HOXA11 |
-1.5 |
Homeobox A11 |
||
|
|
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|
CHST11 |
-1.5 |
Carbohydrate (chondroitin 4) sulfotransferase 11 |
||
|
|
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|
NSDHL |
-1.4 |
NAD(P) dependent steroid dehydrogenase-like |
||
|
|
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|
ZNRD1 |
-1.3 |
Zinc ribbon domain containing 1 |
||
|
|
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|
SMURF1 |
-1.3 |
SMAD specific E3 ubiquitin protein ligase 1 |
||
|
|
||||
|
DNA repair |
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|
|
||||
|
ZSWIM7 |
-1.6 |
Zinc finger, SWIM-type containing 7 |
||
|
|
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|
WDR33 |
-1.5 |
WD repeat domain 33 |
||
|
|
||||
|
ASF1A |
-1.5 |
ASF1 anti-silencing function 1 homolog A (S. cerevisiae) |
||
|
|
||||
|
ATM |
-1.3 |
ataxia telangiectasia mutated |
||
|
|
||||
|
PMS2L1 |
-1.3 |
Postmeiotic segregation increased 2-like 1 |
||
|
|
||||
|
ALKBH2 |
-1.2 |
AlkB, alkylation repair homolog 2 (E. coli) |
||
|
|
||||
|
XRCC6 |
-1.2 |
X-ray repair complementing defective repair in Chinese hamster cells 6 |
||
|
|
||||
|
DCLRE1A |
-1.2 |
DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) |
||
|
|
||||
|
PRPF19 |
-1.2 |
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) |
||
|
|
||||
|
ELN |
2.5 |
Elastin (supravalvular aortic stenosis, Williams-Beuren syndrome) |
||
|
|
||||
|
Cellular biosynthetic process |
||||
|
|
||||
|
PITX2 |
-6.4 |
Paired-like homeodomain 2 |
||
|
|
||||
|
NR3C2 |
-5.8 |
Nuclear receptor subfamily 3, group C, member 2 |
||
|
|
||||
|
GALNT6 |
-4.5 |
Polypeptide N-acetylgalactosaminyltransferase 6 |
||
|
|
||||
|
RGMB |
-2.7 |
RGM domain family, member B |
||
|
|
||||
|
FOXF2 |
-2.2 |
Forkhead box F2 |
||
|
|
||||
|
ZNF529 |
-2.1 |
Zinc finger protein 529 |
||
|
|
||||
|
BARX1 |
-1.9 |
BARX homeobox 1 |
||
|
|
||||
|
DHODH |
-1.9 |
Dihydroorotate dehydrogenase |
||
|
|
||||
|
LMO4 |
-1.8 |
LIM domain only 4 |
||
|
|
||||
|
BRWD1 |
-1.7 |
Bromodomain and WD repeat domain containing 1 |
||
|
|
||||
|
TARS2 |
-1.7 |
Threonyl-tRNA synthetase 2, mitochondrial (putative) |
||
|
|
||||
|
HLX |
-1.7 |
H2.0-like homeobox |
||
|
|
||||
|
BNC2 |
-1.7 |
Basonuclin 2 |
||
|
|
||||
|
PGD |
-1.6 |
Phosphogluconate dehydrogenase |
||
|
|
||||
|
MEIS1 |
-1.6 |
Meis homeobox 1 |
||
|
|
||||
|
ZNF420 |
-1.6 |
Zinc finger protein 420 |
||
|
|
||||
|
ZFP28 |
-1.5 |
Zinc finger protein 28 homolog (mouse) |
||
|
|
||||
|
CARS2 |
-1.5 |
Cysteinyl-tRNA synthetase 2, mitochondrial (putative) |
||
|
|
||||
|
HOXA11 |
-1.5 |
Homeobox A11 |
||
|
|
||||
|
PDLIM1 |
13.2 |
PDZ and LIM domain 1 (elfin) |
||
|
|
||||
|
ITGB2 |
6.6 |
Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
||
|
|
||||
|
LMCD1 |
3.5 |
LIM and cysteine-rich domains 1 |
||
|
|
||||
|
KRT7 |
3.1 |
Keratin 7 |
||
|
|
||||
|
ARNT |
2.3 |
Aryl hydrocarbon receptor nuclear translocator |
||
|
|
||||
|
ZNF415 |
2.2 |
Zinc finger protein 415 |
||
|
|
||||
|
ZNF630 |
2.0 |
Zinc finger protein 630 |
||
|
|
||||
|
INHBA |
1.9 |
Inhibin, beta A |
||
|
|
||||
|
GALNT1 |
1.7 |
Polypeptide N-acetylgalactosaminyltransferase 1 |
||
|
|
||||
|
ENPP1 |
1.7 |
Ectonucleotide pyrophosphatase/phosphodiesterase 1 |
||
|
|
||||
|
Miscellaneous |
||||
|
|
||||
|
PTGES |
3.2 |
Prostaglandin E synthase |
||
|
|
||||
|
ADAMTS5 |
1.7 |
ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) |
||
|
|
||||
|
DSP |
5.2 |
Desmoplakin |
||
|
|
||||
|
FMOD |
2.7 |
Fibromodulin |
||
|
|
||||
|
sFRP4 |
3.4 |
Secreted frizzled-related protein 4 |
||
|
|
||||
|
MCAM |
2.3 |
Melanoma cell adhesion molecule |
||
|
|
||||
|
TNXB |
-1.3 |
Tenascin XB |
||
|
|
||||
|
FUS |
-1.5 |
Fusion (involved in t(12;16) in malignant liposarcoma) |
||
|
|
||||
|
TBX5 |
-1.3 |
T-box 5 |
||
|
|
||||
|
*Positive number indicates elevated expression (fold) in OA meniscal cells compared to normal meniscal cells. Negative number indicates decreased expression (fold) in OA meniscal cells compared to normal meniscal cells. |
||||
|
Sun et al. BMC Musculoskeletal Disorders 2010 11:19 doi:10.1186/1471-2474-11-19 |
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