Open Access Highly Accessed Research article

Identification of symptom and functional domains that fibromyalgia patients would like to see improved: a cluster analysis

Robert M Bennett12*, Jon Russell2, Joseph C Cappelleri3, Andrew G Bushmakin3, Gergana Zlateva4 and Alesia Sadosky4

Author Affiliations

1 Oregon Health & Science University, Portland, Oregon, USA

2 University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

3 Pfizer Global Research and Development, New London, Connecticut, USA

4 Pfizer Global Outcomes Research, New York, New York, USA

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BMC Musculoskeletal Disorders 2010, 11:134  doi:10.1186/1471-2474-11-134

Published: 28 June 2010

Abstract

Background

The purpose of this study was to determine whether some of the clinical features of fibromyalgia (FM) that patients would like to see improved aggregate into definable clusters.

Methods

Seven hundred and eighty-eight patients with clinically confirmed FM and baseline pain ≥40 mm on a 100 mm visual analogue scale ranked 5 FM clinical features that the subjects would most like to see improved after treatment (one for each priority quintile) from a list of 20 developed during focus groups. For each subject, clinical features were transformed into vectors with rankings assigned values 1-5 (lowest to highest ranking). Logistic analysis was used to create a distance matrix and hierarchical cluster analysis was applied to identify cluster structure. The frequency of cluster selection was determined, and cluster importance was ranked using cluster scores derived from rankings of the clinical features. Multidimensional scaling was used to visualize and conceptualize cluster relationships.

Results

Six clinical features clusters were identified and named based on their key characteristics. In order of selection frequency, the clusters were Pain (90%; 4 clinical features), Fatigue (89%; 4 clinical features), Domestic (42%; 4 clinical features), Impairment (29%; 3 functions), Affective (21%; 3 clinical features), and Social (9%; 2 functional). The "Pain Cluster" was ranked of greatest importance by 54% of subjects, followed by Fatigue, which was given the highest ranking by 28% of subjects. Multidimensional scaling mapped these clusters to two dimensions: Status (bounded by Physical and Emotional domains), and Setting (bounded by Individual and Group interactions).

Conclusion

Common clinical features of FM could be grouped into 6 clusters (Pain, Fatigue, Domestic, Impairment, Affective, and Social) based on patient perception of relevance to treatment. Furthermore, these 6 clusters could be charted in the 2 dimensions of Status and Setting, thus providing a unique perspective for interpretation of FM symptomatology.