Open Access Highly Accessed Research article

Gel-type autologous chondrocyte (Chondron™) implantation for treatment of articular cartilage defects of the knee

Nam-Yong Choi1, Byoung-Woo Kim2, Woo-Jin Yeo3, Haeng-Boo Kim4, Dong-Sam Suh5, Jin-Soo Kim6, Yoon-Sik Kim7, Yong-Ho Seo8, Jea-Yeong Cho9, Chung-Woo Chun10, Hyun-Shin Park5, Asode Ananthram Shetty11 and Seok-Jung Kim12*

Author Affiliations

1 Department of Orthopedic Surgery St. Paul's Hospitial The Catholic University of Korea 620-56, Jeonnong 1-dong, Dongdaemun-gu, Seoul, 130-021 Korea

2 The Department of Orthopedic Surgery The Leon Wiltse Memorial Hospital 994-3, Ingye-dong, Paldal-gu, Suwon-si, Gyeonggi-do, 442-070 Korea

3 Department of Orthopedic Surgery Barunsesang Hospital 355-5, Yatap-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-828 Korea

4 Haeng-Boo, Kim Orthopeadic Surgery , Myeongil-dong, Gangdong-gu, Seoul, 134-070 Korea

5 RMS, SewonCellontech, 273-15, Seongsu 2-ga 3-dong, Seongdong-gu, Seoul, 133-831 Korea

6 Department of Orthopedic Surgery Hyundae Hospital, 663, Janghyeon-ri, Jinjeop-eup, Namyangju-si, Gyeonggi-do, 472-865 Korea

7 Department of Orthopedic Surgery, New Korea Hospital 1764, Janggi-dong, Gimpo-si, Gyeonggi-do, 415-060 Korea

8 Department of Orthopedic Surgery, Changwon Jungang Hospital 5, Namyang-dong, Changwon-si, Gyeongsangnam-do, 641-802 Korea

9 Center for Sport Medicine, JY Cho Orthgopedic Surgery Clinic 699, Tanbang-dong, Seo-gu, Daejeon, 302-223 Korea

10 Department of Orthopedic Surgery Murup Hospital, Jungang-dong 3-ga, Masan-si, Gyeongsangnam-do, 631-716 Korea

11 King's College Hospital, Denmark Hill, London SE5 9RS, UK

12 Orthopedic Department, Uijeongbu St. Mary's Hospital, Kumoh-dong, Uijeongbu City, Gyeonggi-do, 480-717, Korea

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BMC Musculoskeletal Disorders 2010, 11:103  doi:10.1186/1471-2474-11-103

Published: 28 May 2010

Abstract

Background

Gel-type autologous chondrocyte (Chondron™) implantations have been used for several years without using periosteum or membrane. This study involves evaluations of the clinical results of Chondron™ at many clinical centers at various time points during the postoperative patient follow-up.

Methods

Data from 98 patients with articular cartilage injury of the knee joint and who underwent Chondron™ implantation at ten Korean hospitals between January 2005 and November 2008, were included and were divided into two groups based on the patient follow-up period, i.e. 13~24-month follow-up and greater than 25-month follow-up. The telephone Knee Society Score obtained during telephone interviews with patients, was used as the evaluation tool.

Results

On the tKSS-A (telephone Knee Society Score-A), the score improved from 43.52 ± 20.20 to 89.71 ± 13.69 (P < 0.05), and on the tKSS-B (telephone Knee Society Score-B), the score improved from 50.66 ± 20.05 to 89.38 ± 15.76 (P < 0.05). The total improvement was from 94.18 ± 31.43 to 179.10 ± 24.69 (P < 0.05).

Conclusion

Gel-type autologous chondrocyte implantation for chondral knee defects appears to be a safe and effective method for both decreasing pain and improving knee function.