Table 10 |
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Covariate variable derivations |
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Variable |
Definition |
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RV |
Residual Volume by Spirometry and Plethysmography (TLC - Max (FVC or VC)) |
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TLC |
Total Lung Capacity by Plethysmography |
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VC |
Vital Capacity by Plethysmography |
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FVC |
Forced Vital Capacity by Spirometry |
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FEV1 |
Forced Expiratory Volume in the First Second by Spirometry |
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Target Lobe |
RUL, RLL, LUL, or LLL |
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RUL |
RUL Target vs. Others |
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Density Score |
Density Score by Lobe |
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Total Density Score |
Sum of all Lobar Density Scores (including RML) |
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Ipsilateral DS Heterogeneity |
Target - Max DS of Non-treated Lobes within Treated Lung [e.g.: RUL - Max(RML, RLL)] |
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Thorax DS Heterogeneity |
Target DS - Max DS of All Non-treated Lobes [e.g.: RUL - MAX (RML, RLL, LUL, LLL)] |
|
Target Lobe DS % Delta |
(TLC HRCT - RV HRCT)/TLC HRCT Density Score of Target Lobe |
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Target Lobe Volume % Delta |
(TLC HRCT Volume - RV HRCT)/TLC HRCT Volume of Target Lobe |
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Fissure Score |
Categorical Fissure Assessment Surrounding Target Lobe |
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1 = Absent |
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2 = Incomplete |
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3 = Complete |
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NETT Strata |
1 = Upper-Lobe Predominance, Low Baseline Exercise Capacity* |
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2 = Upper-Lobe Predominance, High Baseline Exercise Capacity |
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3 = Non-Upper-Lobe Predominance, Low Baseline Exercise Capacity |
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4 = Non-Upper-Lobe Predominance, High Baseline Exercise Capacity |
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Target Lobe Atelectasis Scores |
% change in Target Lobe Volume at TLC and at RV between Baseline and 180-day HRCT |
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Lobar Exclusion |
Yes, If all bronchial pathways to target lobe are sealed by valve(s) – adjudicated by HRCT Core Lab |
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Valve Combinations |
1. Small ONLY |
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2. Small AND Large |
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3. Large Only |
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Large Valve |
Any procedure with Only Large Valves vs. all others |
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Small Valve |
Any procedure with Only Small Valves vs. all others |
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*Low Exercise Capacity by Cycle Ergometry ≤ 25 W for Women, ≤ 40 W for Men |
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Strange et al. BMC Pulmonary Medicine 2007 7:10 doi:10.1186/1471-2466-7-10 |
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