Table 2

Change in lung function and pulmonary inflammation occurring after receiving an allograft haematopoietic stem cell transplant
Time after stem cell transplant
Baseline 6 weeks 3 months 6 months
Mean percent predicted FEV1 (sd) 90.3 (15.8) 84.0 (18.9) 86.0 (19.6) 85.5 (19.4)
N=68 N=64 N=57 N=47
Change in percent predicted FEV1 from baseline (95% CI) - - 5.9 −4.7 −4.3
(−8.9 to −2.9) (−8.4 to −1.0) (−7.7 to −0.9)
p<0.001 p=0.007 p=0.007
Number with decrease in predicted FEV1 by ≥15% (%) - 10 10 8
(16) (18) (17)
Mean percent predicted FVC (sd) 98.6 (15.7) 91.4 (18.1) 93.1 (18.6) 94.1 (17.1)
N=68 N=61 N=56 N=47

Change in FVC from baseline

(95% CI)

−6.4 −5.3 −5.6
- (−9.7 to −3.0) (−9.1 to −1.5) (−9.1 to −2.2)
p<0.001 p=0.008 p=0.002
Number with decrease in predicted FVC by ≥15% (%) - 15 10 11
(25) (18) (23)
FEV1/FVC (sd) 76 (9) 76 (10) 77 (9) 76 (11)
N=68 N=61 N=56 N=47
Median exhaled nitric oxide, ppb, (IQR) 15 (12–25) 18.5 (12–27) 19 (15–28) 20 (16–27)
N=59* N=54* N=43* N=38*
Change in exhaled nitric oxide from baseline, ppb (95% CI) +2.1 +6.0 +6.4
- (−1.8 to +5.9) (+0.4 to +11.5) (+0.7 to +12.1)
p=0.283 p=0.034 p=0.028
N=48 N=40 N=36
Number with increase in exhaled NO by ≥10ppb (%) - 10 11 13
(21) (27) (36)

FEV1- Forced Expiratory Volume in one second.

FVC- Forced Vital Capacity.

CI- Confidence intervals.

IQR- Interquartile range.

NO= Nitric oxide.

* the numbers of patients with exhaled nitric oxide measurements are lower then those with lung function as this was added after data collection had begun. Statistical comparisons using paired t-tests.

Enocson et al.

Enocson et al. BMC Pulmonary Medicine 2013 13:2   doi:10.1186/1471-2466-13-2

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