Table 2 |
||||
Change in lung function and pulmonary inflammation occurring after receiving an allograft haematopoietic stem cell transplant | ||||
Time after stem cell transplant | ||||
Baseline | 6 weeks | 3 months | 6 months | |
Mean percent predicted FEV_{1} (sd) | 90.3 (15.8) | 84.0 (18.9) | 86.0 (19.6) | 85.5 (19.4) |
N=68 | N=64 | N=57 | N=47 | |
Change in percent predicted FEV_{1} from baseline (95% CI) | - | - 5.9 | −4.7 | −4.3 |
(−8.9 to −2.9) | (−8.4 to −1.0) | (−7.7 to −0.9) | ||
p<0.001 | p=0.007 | p=0.007 | ||
Number with decrease in predicted FEV_{1} by ≥15% (%) | - | 10 | 10 | 8 |
(16) | (18) | (17) | ||
Mean percent predicted FVC (sd) | 98.6 (15.7) | 91.4 (18.1) | 93.1 (18.6) | 94.1 (17.1) |
N=68 | N=61 | N=56 | N=47 | |
Change in FVC from baseline (95% CI) |
−6.4 | −5.3 | −5.6 | |
- | (−9.7 to −3.0) | (−9.1 to −1.5) | (−9.1 to −2.2) | |
p<0.001 | p=0.008 | p=0.002 | ||
Number with decrease in predicted FVC by ≥15% (%) | - | 15 | 10 | 11 |
(25) | (18) | (23) | ||
FEV_{1}/FVC (sd) | 76 (9) | 76 (10) | 77 (9) | 76 (11) |
N=68 | N=61 | N=56 | N=47 | |
Median exhaled nitric oxide, ppb, (IQR) | 15 (12–25) | 18.5 (12–27) | 19 (15–28) | 20 (16–27) |
N=59* | N=54* | N=43* | N=38* | |
Change in exhaled nitric oxide from baseline, ppb (95% CI) | +2.1 | +6.0 | +6.4 | |
- | (−1.8 to +5.9) | (+0.4 to +11.5) | (+0.7 to +12.1) | |
p=0.283 | p=0.034 | p=0.028 | ||
N=48 | N=40 | N=36 | ||
Number with increase in exhaled NO by ≥10ppb (%) | - | 10 | 11 | 13 |
(21) | (27) | (36) |
FEV_{1}- Forced Expiratory Volume in one second.
FVC- Forced Vital Capacity.
CI- Confidence intervals.
IQR- Interquartile range.
NO= Nitric oxide.
* the numbers of patients with exhaled nitric oxide measurements are lower then those with lung function as this was added after data collection had begun. Statistical comparisons using paired t-tests.
Enocson et al.
Enocson et al. BMC Pulmonary Medicine 2013 13:2 doi:10.1186/1471-2466-13-2