24-hour spirometry results at steady-state (modified intent-to-treat population). Model-based placebo-adjusted values for OD and BID dosing regimens, with 90% confidence limits (red and blue shaded areas, respectively). MCID = 100 mL . MCID: minimal clinically important difference; FEV1: forced expiratory volume in one second; OD: once daily; BID: twice daily.
Arievich et al. BMC Pulmonary Medicine 2012 12:74 doi:10.1186/1471-2466-12-74