Table 3

Disease-related characteristics of the COPD patients according to anxiety or depression status
Anxiety status pValue Depression status pValue
Yes (n = 201) No (n = 899) Yes (n = 393) No (n = 707)
HADS-A score (mean, sd) 10.4(3.1) 3.5(2.1) <0.05 NA NA NA
HADS-D score (mean, sd) NA NA NA 10.5(3.6) 4.1(3.3) <0.05
BMI (kg/m2) (mean, sd) 22.5(2.7) 23.7(2.8) <0.05 23.4(2.9) 22.2(3.0) <0.05
FEV1 (L) 1.29(0.35) 1.30(0.33) >0.05 1.25(0.34) 1.29(0.35) <0.05
6MWD (m) (mean, sd) 408.5(78.6) 456.8 (95.5) <0.05 401.5(88.5) 460.6(100.5) <0.05
MRC score (mean, 5th-95th) 2(0–4) 1(0–2) <0.05 2(0–4) 1(0–2) <0.05
BODE index (mean, 5th-95th) 4(1–8) 2.5(1–6) <0.05 3.5(1–8) 2.5(1–6) <0.05
SGRQ score (mean, 5th-95th)
 Symptom 72.5(19.5) 63.5(21.0) <0.05 70.0(17.5) 62.0(18.7) <0.05
 Activity 66.3(16.8) 48.0(18.4) <0.05 61.3(17.5) 47.8(19.5) <0.05
 Effect 56.6(18.2) 32.0(15.4) <0.05 48.0(18.6) 30.7(18.8) <0.05
 Total 61.5(17.3) 40.6(16.4) <0.05 55.3(16.2) 40.4(17.8) <0.05
COPD severity (Percentage%)
 I 14(7.0) 149(16.6) <0.05 25(6.4) 138(19.5) <0.05
 II 70(34.8) 390(43.4) <0.05 118(30.0) 342(48.4) <0.05
 III 65(32.3) 224(24.9) <0.05 123(31.3) 166(23.5) <0.05
 IV 52(25.9) 136(15.1) <0.05 127(32.3) 61(8.6) <0.05
Comorbid anxiety NA NA NA 165(42.0) 36(5.1) <0.05
Comorbid depression 145(72.1) 248(27.6) <0.05 NA NA NA
Female sex 41(20.4) 232(25.8) <0.05 112(28.5) 161(22.7) <0.05

HADS: Hospital Anxiety and Depression Scale: HADS-A: HADS—anxiety; HADS-D: HADS—depression; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; BMI:body mass index; 6MWD: six-minute walking distance; MRC: Medical Research Council; SGRQ: Saint George’s Respiratory Questionnaire: BODE: body mass index, degree of airway obstruction, dyspnea and exercise capacity; Possible anxiety (8 ≤ HADS-A ≤ l0) and probable anxiety (HADS-A ≥ 11) were combined and referred to as anxiety (HADS-A ≥ 8). Possible depression (8 ≤ HADS-D ≤ l0) and probable depression (HADS-D ≥ 11) were combined and referred to and as depression (HADS-D ≥ 8).

Lou et al.

Lou et al. BMC Pulmonary Medicine 2012 12:53   doi:10.1186/1471-2466-12-53

Open Data