Progressive dyspnoea following the treatment of Mycobacterium abscessus infection in an individual with relapsing granulamatosis with polyangitis (Wegener’s), complicated by hearing loss requiring cochlear implantation
1 Consultant in Internal Medicine & Nephrology Cypress Regional Hospital 2004 Saskatchewan Dr., Swift Current, Saskatchewan, S9H 5M8, Canada
2 Cypress Regional Hospital 2004 Saskatchewan Dr. Swift Current, Saskatchewan, S9H 5M8, Canada
BMC Pulmonary Medicine 2012, 12:47 doi:10.1186/1471-2466-12-47Published: 4 September 2012
Granulomatosis with polyangitis (Wegener’s) is a vasculitic disease predominantly affecting the lungs, skin, kidneys, ears, nose and throat. Mycobacterium abscessus is an uncommon rapidly growing mycobacterium causing sporadic lung disease. This is the first report of both GPA and Mycobacterium abscessus pulmonary disease reported in literature.
We present a case report of a 33 year old Caucasian man with relapsing disease complicated by pulmonary infection with Mycobacterium abscessus. He subsequently required bilateral cochlear implantation for progressive sensori-neural hearing loss. His M. abscessus was treated successfully with a prolonged course of antimicrobial therapy. His Granulomatosis with polyangitis (Wegener’s) relapsed towards the end of antimicrobial therapy and required treatment. Shortly after completing his antimicrobial therapy and relapse, he developed progressive dyspnea due to pulmonary fibrosis.
The potential causes of his progressive dyspnoea are discussed including the potential role of his underlying disease and treatment.