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Open Access Highly Accessed Research article

The month of July: an early experience with pandemic influenza A (H1N1) in adults with cystic fibrosis

Megan W France1*, Szeanna Tai1, Phillip J Masel1, Vanessa L Moore1, Tracy L McMahon1, Alexander J Ritchie1 and Scott C Bell12

Author Affiliations

1 The Prince Charles Hospital Adult Cystic Fibrosis Centre, Rode Rd, Chermside, Queensland, 4032, Australia

2 The University of Queensland, St Lucia, Queensland, 4072, Australia

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BMC Pulmonary Medicine 2010, 10:8  doi:10.1186/1471-2466-10-8

Published: 25 February 2010

Abstract

Background

Pandemic Influenza A (H1N1) 2009 is a novel viral infection that emerged in March 2009. This is the first report addressing the clinical course of patients with cystic fibrosis (CF) and H1N1 infection.

Methods

All patients with an influenza-like illness (ILI) attending our adult centre during July 2009 were identified. Baseline respiratory function, nutritional status, approach to management and short-term clinical course were recorded.

Results

Most patients experienced a mild course and were able to be managed with antiviral agents as an outpatient. Robust infection control policies were implemented to limit transmission of H1N1 infection within our CF centre. Patients with severe lung disease, poor baseline nutritional reserve and presenting with more than 48 hours of ILI experienced a more severe course. Prompt antiviral therapy within the first 48 hours of illness may have been important in improving outcomes.

Conclusions

This observational study demonstrates that most adults with CF with H1N1 infection had mild clinical courses and recovered rapidly.