Email updates

Keep up to date with the latest news and content from BMC Public Health and BioMed Central.

Open Access Study protocol

Repeat infection with Chlamydia trachomatis: a prospective cohort study from an STI-clinic in Stockholm

Karin Edgardh1*, Sharon Kühlmann-Berenzon2, Maria Grünewald2, Maria Rotzen-Östlund3, Ivar Qvarnström1 and Jennie Everljung1

Author Affiliations

1 Dept of Obstetrics and Gynecology, Sesam City, Karolinska University Hospital Solna, Stockholm, Sweden

2 Dept of Epidemiology, Swedish Institute for Infectious Disease Control, Nobels väg 18, 171 82 Solna, Sweden

3 Dept of Clinical Microbiology, Karolinska Institute/Karolinska University Hospital Solna, Stockholm, Sweden

For all author emails, please log on.

BMC Public Health 2009, 9:198  doi:10.1186/1471-2458-9-198

Published: 22 June 2009

Abstract

Background

Infection with genital Chlamydia trachomatis (Ct) is the most common notifiable sexually transmitted infection (STI) in Sweden. A mutated Chlamydia, nvCT, has contributed to the increase. The occurrence of repeat infections is not investigated in Sweden. The current paper presents the study protocol for the first Swedish clinical investigation of repeat Chlamydial infection. The concern of the study is whether a Chlamydia infection at inclusion indicates an increased risk for Chlamydia at follow-up after 6–8 months, gender-specific risk factors for and clinical presentation of repeat infections.

Methods and design

Sesam City is a drop-in clinic in the city centre of Stockholm. Patients 20 years and older are admitted. During 2007, the clinic had 15 000 visits, 60% made by men. In December 2007, a cohort study began, and data collection was finished in April 2009. A total of 2813 study participants aged 20–39 years were recruited. Data collection included an anonymous self-administered paper-and-pen questionnaire on sexual behaviour, reproductive health and history of Chlamydia, and condom use. Chlamydia tests were performed by self-sampled specimens, analyzed by the ProbeTec (Becton Dickinson) method, Ct-positive specimens also analyzed with a nvCT-specific method. Data from medical records were summarized in clinical report forms. Patients positive for Chlamydia were retested 4 weeks after treatment. Contact tracing covered sexual contacts during the last 12 months. At follow-up 6–8 months after inclusion, Chlamydia tests were performed, and a new questionnaire and CRF completed.

Discussion

A STI-clinic-based prospective cohort study allowed us to survey 2813 adult patients. The collected data will provide gender-specific information on the occurrence of and risk for repeat Chlamydia infection, the occurrence of nvCT, and clinical data and information on sexual behaviour and reproductive health, risk-taking and condom use.