Table 5

Summary of studies reporting comorbidities with cardiovascular disease.

Comorbidity Study

Study Quality Score/8

Arthritis

(%)

Asthma

(%)

CVD

(%)

Diabetes

(%)

Dyslipidemia

(%)

Hypertension

(%)

Malignancy

(%)

Mental problem/

depression#

(%)


Cardiovascular Disease


NHS 2004–05 [2] ≥ 65 yrs n = 3,212 HSVDa self-report all conditions (prevalence 18.4%)

7

57.9

10.3

19.8

-

-

8.4

10.5

Krum et al, 2006 [44] mean age 64 yrs, n = 479, admission to hospital for MIa, comorbidities from hospital administrative data and records

4

-

-

24.2 (CHFa)

21.6

52.9

53.4

-

-

O'Halloran et al, 2003 [42] ≥ 65 yrs n = 2,976 GP encounters (IHDa prevalence 16.9%)

5

23.1 (OA)

-

20.1

23.1

47.3

-

9.5#

Parker et al, 2006 [37] mean age 63 yrs, n = 489 hospital admission for ACSa, depression assessed by CIDIb, comorbidities self-report

5

34.6 (pMIa)

17.3

63.5

10.6

Simons et al, 2002 [45] ≥ 60 yrs n = 2,217 (Dubbo study) hospital admission for MIa (prevalence 18.7%), comorbidities from medical history and clinical examination

6

-

-

36.0 (pCSa)

16.0

26.9

62.0

-

Krum et al, 2001 [46], ≥ 60 yrs, n = 22,060, GP diagnosis CHFa (prevalence 13.2%), comorbidities from hospital administrative data and records

5

-

-

44.8 (angina)

29.7 (pMIa)

-

-

68.3

-

-

Stewart et al, 2001 [41] ≥ 55 yrs (mean age 76 yrs) n = 200 hospital admission CHFa, comorbidities hospital discharge data

4

-

36.0 (CADa)

78.0 (IHDa)

70.0 (pMI)

32.0

-

66.0

-

-

O'Halloran et al, 2003 [42] ≥ 65 yrs n = 2976 GP encounters (HTc prevalence 45.6%)

5

23.3 (OA)

-

17.5 (IHDa)

16.7

23.7

-

9.0#

Sturm et al, 2004 [47] mean age 71 yrs, n = 226 (NEMESIS)a, stroke detected & diagnosed by medical practitioner, comorbidities by past medical history and/or current presentation (diabetes or AFa)

5

-

-

23.5 (AFa)

6.2 (PVDa) 8.8 (pMIa)

19.1

-

58.9

-

-


NHS 2004–05 [2] ≥ 25 yrs n = 17,202 HSVD self-report all conditions (prevalence 5.7%)

7

54.4d

12.6

19.2

-

-

7.0d

14.0d

Powell et al, 2001 [48], 20–85 yrs (mean age 66 yrs) n = 1765, hospital admission for HD (AMI, angina, IHD, CHF)c ICD-9 CM, comorbidities extracted from medical records and coded to corresponding ICD-9 CM diagnosis codes

4

2.2 (RAa)

14.6 (CALa)

12.7 (Arra)

11.5 (CVa) 8.2 (PVDa)

18.4

22.8

47.7

3.3

-

Burvill et al, 1997 [39] all ages, n = 191 (Perth community stroke study), first ever stroke (physician diagnosis), self-report co-morbidities at time of strokee

4

-

-

18.0 (pMI)

31.0 ((angina)

12.0

-

62.0

-

8.2#e


-, not reported; a(HSVD, Heart, Stroke and Vascular Disease, includes ischaemic heart disease (IHD), cerebrovascular disease (CV), oedema and chronic heart failure (CHF) and diseases of the arteries, arterioles and capillaries), MI myocardial infarction, ACS acute coronary syndrome (includes MI or unstable angina), pMI previous MI, pCS prior coronary syndrome, CAD chronic airways disease, NEMESIS North East Melbourne Stroke Incidence Study, AF atrial fibrillation, PVD peripheral vascular disease, HD heart disease, RA rheumatoid arthritis, CAL chronic airway limitation (asthma, emphysema), Arr arrhythmia; b Current depression assessed by Composite International Diagnostic Interview (CIDI) used the DSM symptom and duration criteria that included at least two or more weeks of major depression and/or two or more years of dysthmia, hence excluded individuals that developed depression at or around the time of their ACS and admission; c HT; hypertension defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, or use of antihypertensive drugs; d ≥ 45 years, data for 25 years and over were reported to have a high standard error and were deemed to be used with caution2; e n = 208, for study cohort that includes those depressed (n = 17) at time of stroke.

Caughey et al. BMC Public Health 2008 8:221   doi:10.1186/1471-2458-8-221

Open Data