Table 2

Course of outcome parameters and estimated mean changes of outcome parameters





Estimated changes compared to baseline†

Baseline
 3 months
 12 months
 24 month
 Δ 3 months
 Δ 12 months
 Δ 24 months

mean ± SD
 mean ± SD
 mean ± SD
 mean ± SD
 mean (95%CI)
 mean (95%CI)
 mean (95%CI)
Adults
     Patients assessments (NRS) ‡
 6.2 ± 1.7
 3.8 ± 2.2*
 3.3 ± 2.1*
 2.9 ± 2.2*
 -2.4 (-2.5 to -2.3)
 -2.8 (-2.9 to -2.7)
 -3.1 (-3.2 to -3.0)
     Physicians assessments (NRS) ‡
 6.0 ± 1.6
 3.9 ± 2.1*
 2.8 ± 2.1*
 2.1 ± 2.0*
 -2.1 (-2.2 to -2.0)
 -3.1 (-3.2 to -3.0)
 -3.7 (-3.8 to -3.6)
     SF-36 QoL physical scale
 46.5 ± 10.1
 49.1 ± 9.5*
 50.1 ± 9.6*
 50.7 ± 9.5*
 2.6 (2.3 to 2.9)
 3.5 (3.0 to 3.9)
 4.1 (3.5 to 4.6)
     SF-36 QoL mental scale
 39.3 ± 11.8
 44.6 ± 10.8*
 45.5 ± 10.8*
 46.4 ± 10.6*
 5.6 (5.2 to 6.0)
 6.2 (5.7 to 6.7)
 6.9 (6.3 to 7.6)
Children
     Patients assessments (NRS) ‡
 6.1 ± 1.8
 3.2 ± 2.3*
 2.5 ± 2.1*
 2.2 ± 2.0*
 -3.1 (-3.3 to -2.9)
 -3.5 (-3.7 to -3.4)
 -3.9 (-4.0 to -3.7)
     Physicians assessments (NRS) ‡
 5.9 ± 1.7
 3.2 ± 2.2*
 2.0 ± 1.5*
 1.5 ± 1.8*
 -2.7 (-2.8 to -2.6)
 -3.8 (-4.0 to -3.7)
 -4.4 (-4.6 to -4.3)
     KINDL QoL
 69.3 ± 13.3
 72.1 ± 12.6
 68.0 ± 9.2
 67.3 ± 9.9*
 2.7 (1.7 to 3.7)
 -0.4 (-1.5 to 0.8)
 -2.2 (-3.6 to -0.8)
     KITA QoL mental/physical dimension
 67.6 ± 16.9
 75.4 ± 14.6*
 77.0 ± 14.1*
 77.5 ± 14.3*
 8.3 (6.6 to 10.0)
 9.3 (7.7 to 10.8)
 10.0 (8.3 to 11.6)
     KITA QoL aspects of daily living
 58.6 ± 18.3
 66.9 ± 15.9*
 69.1 ± 16.7*
 70.6 ± 16.0*
 8.5 (7.2 to 9.8)
 10.4 (8.8 to 12.0)
 11.6 (9.7 to 13.5)

† estimations are based on generalised linear models, see text; ‡ = lower values indicate better status and negative Δ indicates improvement

QoL = quality of life; NRS = numeric rating scale, * p < 0.001 versus baseline

Witt et al. BMC Public Health 2005 5:115   doi:10.1186/1471-2458-5-115