Table 5

Risk of generalized vaccinia (G.V.) and accidental infection (A.I.) from primary smallpox vaccinations, Stratified by age and study, 1963–1968

Generalized vaccinia

Accidental infection


Age group and studies

Number vaccinated

G.V. No.

Deaths No.

Risk of complication per million (95% C.I.)a

Number vaccinated

A.I. No.

Deaths No.

Risk of complication per million (95% C.I.)a


Age <1

Neff 1967a

654,000

52

0

79.5

(59.4, 104)

654,000

7

0

10.7

(4.3, 22.0)

Neff 1967b

31,000

12

0

387.1

(200, 676)

n/a

n/a

n/a

n/a

n/a

Lane 1969

614,000

43

0

70.0

(50.7, 94.3)

614,000

7

0

11.4

(4.6, 23.5)

Lane 1970

17,000

28

0

1647

(1095, 2380)

17,000

36

0

2117.6

(1484, 2930)

Ratner 1970

1

1

0

n/c

n/c

1

0

0

n/c

n/c

Neff 1972

32

0

0

n/c

n/c

32

0

0

n/c

n/c

Summary

1,316,033

136

0

103.3

(86.7, 122.2)

1,285,033

50

0

38.9

(28.9, 51.3)

Age 1 to 4

Neff 1967a

2,973,000

46

0

15.5

(11.3, 20.6)

2,973,000

40

0

13.4

(9.6, 18.3)

Neff 1967b

142,000

24

0

169.0

(108, 251)

n/a

n/a

n/a

n/a

n/a

Lane 1969

2,733,000

47

0

17.2

(12.6, 22.9)

2,733,000

91

0

33.3

(26.8, 40.9)

Lane 1970

317,000

74

0

233.4

(183, 293)

317,000

183

0

577.3

(497, 667)

Ratner 1970

68,002

6

0

88.2

(32.4, 192)

68,002

3

0

44.1

(9.1, 129)

Neff 1972

517

0

0

0.0

(0.0, 7110)

517

3

0

5802.7

(1198, 16,864)

Summary

6,233,519

197

0

31.6

(27.3, 36.3)

6,091,519

320

0

52.5

(46.9, 58.6)

Age 5 to 19

Neff 1967a

2,295,000

24

0

10.5

(6.7, 15.6)

2,295,000

33

0

14.4

(9.9, 20.2)

Neff 1967b

110,000

17

0

154.5

(90.0, 247)

n/a

n/a

n/a

n/a

n/a

Lane 1969

1,959,000

25

0

12.8

(8.3, 18.8)

1,959,000

35

0

17.9

(12.4, 24.8)

Lane 1970

229,000

32

0

139.7

(95.6, 197)

229,000

85

0

371.2

(296, 459)

Ratner 1970b

193,721

9

0

46.5

(21.2, 88.2)

193,721

2

0

10.3

(1.2, 37.3)

Summary

4,786,721

107

0

22.4

(18.3, 27.0)

4,676,721

155

0

33.1

(28.1, 38.8)

Age 20 +

Neff 1967a

317,000

6

0

18.9

(6.9, 41.2)

317,000

4

0

12.6

(3.4, 32.3)

Neff 1967b

15,000

2

0

133.3

(16.1, 482)

n/a

n/a

n/a

n/a

n/a

Lane 1969

288,000

13

0

45.1

(24.0, 77.2)

288,000

4

0

13.9

(3.8, 35.6)

Lane 1970

33,000

7

0

212.1

(85.3, 437)

33,000

20

0

606.1

(370, 936)

Ratner 1970b

107,822

10

0

92.7

(44.5, 171)

107,822

8

0

74.2

(32.0, 146)

Summary

760,822

38

0

49.9

(35.3, 68.6)

745,822

36

0

48.3

(33.8, 66.8)

All agesc

Neff 1967a

6,239,000

130

0

20.8

(17.4, 24.7)

6,239,000

85

0

13.6

(10.9, 16.8)

Neff 1967b

298,000

71

0

238.3

(186.1, 300)

298,000

250

0

838.9

(738, 950)

Lane 1969

5,594,000

131

0

23.4

(19.6, 27.8)

5,594,000

142

0

25.4

(21.4, 23.0)

Lane 1970

596,000

157

0

263.4

(224, 308)

596,000

344

0

577.2

(518, 641)

Mellin 1970

109,000

12

0

110.1

(56.9, 192)

109,000

20

0

183.5

(112, 283)

Ratner 1970

369,546

26

0

70.4

(46.0, 103)

369,546

13

0

35.2

(18.7, 60.1)

Neff 1972

549

0

0

0.0

(0.0, 6697)

549

3

0

5464.5

(1128, 15,885)

Summary

13,206,095

527

0

39.9

(36.6, 43.5)

13,206,095

857

0

64.9

(60.6, 69.4)


n/c = not calculated, n/a = not available from this study aRisk and confidence intervals not calculated (n/c) for less that 100 vaccinations. Exact confidence intervals based on the binomial distribution. bThe Ratner study age groups, "Age 5 to 14" and "Age 15+", were counted in the Table age groups "Age 5 to 19" and "Age 20+", respectively. cAll ages group includes subjects whose age was unknown

Aragón et al. BMC Public Health 2003 3:26   doi:10.1186/1471-2458-3-26

Open Data