Table 4 |
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|
Risk of eczema vaccinatum (E.V.) and death from primary smallpox vaccinations, Stratified by age and study, 1963–1968 |
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|
Age group and studies |
Number vaccinated |
E.V. No. |
Deaths No. |
Risk of complication per million (95% C.I.)a |
Risk of death per million (95% C.I.)a |
Case fatality risk per hundred (95% C.I.)a |
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|
|
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|
Age <1 |
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|
Neff 1967a |
654,000 |
16 |
0 |
24.5 |
(14.0, 39.7) |
0.0 |
(0.0, 5.6) |
0.0 |
(0.0, 20.6) |
|
Neff 1967b |
31,000 |
3 |
0 |
96.8 |
(20.0, 283) |
0.0 |
(0.0, 119) |
0.0 |
(0.0, 70.8) |
|
Lane 1969 |
614,000 |
5 |
0 |
8.1 |
(2.6, 19.0) |
0.0 |
(0.0, 6.0) |
0.0 |
(0.0, 52.2) |
|
Lane 1970 |
17,000 |
1 |
0 |
58.8 |
(1.5, 328) |
0.0 |
(0.0, 217) |
0.0 |
(0.0, 97.5) |
|
Ratner 1970 |
1 |
0 |
0 |
n/c |
n/c |
n/c |
n/c |
n/a |
n/a |
|
Neff 1972 |
32 |
0 |
0 |
n/c |
n/c |
n/c |
n/c |
n/a |
n/a |
|
Summary |
1,316,033 |
25 |
0 |
19.0 |
(12.3, 28.0) |
0.0 |
(0.0, 2.8) |
0.0 |
(0.0, 13.7) |
|
Age 1 to 4 |
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|
Neff 1967a |
2,973,000 |
22 |
0 |
7.4 |
(4.6, 11.2) |
0.0 |
(0.0, 1.2) |
0.0 |
(0.0, 15.4) |
|
Neff 1967b |
142,000 |
9 |
0 |
63.4 |
(29.0, 120) |
0.0 |
(0.0, 26.0) |
0.0 |
(0.0, 33.6) |
|
Lane 1969 |
2,733,000 |
31 |
0 |
11.3 |
(7.7, 16.1) |
0.0 |
(0.0, 1.3) |
0.0 |
(0.0, 11.2) |
|
Lane 1970 |
317,000 |
14 |
0 |
44.2 |
(24.1, 74.1) |
0.0 |
(0.0, 11.6) |
0.0 |
(0.0, 23.2) |
|
Ratner 1970 |
68,002 |
0 |
0 |
0.0 |
(0.0, 54.2) |
0.0 |
(0.0, 54.2) |
n/a |
n/a |
|
Neff 1972 |
517 |
0 |
0 |
0.0 |
(0.0, 7110) |
0.0 |
(0.0, 7110) |
n/a |
n/a |
|
Summary |
6,233,519 |
76 |
0 |
12.2 |
(9.6, 15.3) |
0.0 |
(0.0, 0.6) |
0.0 |
(0.0, 4.7) |
|
Age 5 to 19 |
|||||||||
|
Neff 1967a |
2,295,000 |
15 |
0 |
6.5 |
(3.7, 10.8) |
0.0 |
(0.3, 1.6) |
0.0 |
(0.0, 21.8) |
|
Neff 1967b |
110,000 |
8 |
0 |
72.7 |
(31.4, 143) |
0.0 |
(0.3, 33.5) |
0.0 |
(0.0, 36.9) |
|
Lane 1969 |
1,959,000 |
14 |
0 |
7.1 |
(3.9, 12.0) |
0.0 |
(0.3, 1.9) |
0.0 |
(0.0, 23.2) |
|
Lane 1970 |
229,000 |
8 |
0 |
34.9 |
(15.1, 68.8) |
0.0 |
(0.3, 16.1) |
0.0 |
(0.0, 36.9) |
|
Ratner 1970b |
193,721 |
3 |
0 |
15.5 |
(3.2, 45.3) |
0.0 |
(0.3, 19.0) |
0.0 |
(0.0, 70.8) |
|
Summary |
4,786,721 |
48 |
0 |
10.0 |
(7.4, 13.3) |
0.0 |
(0.0, 0.8) |
0.0 |
(0.0, 7.4) |
|
Age 20 + |
|||||||||
|
Neff 1967a |
317,000 |
1 |
0 |
3.2 |
(0.1, 17.6) |
0.0 |
(0.3, 11.6) |
0.0 |
(0.0, 97.5) |
|
Neff 1967b |
15,000 |
1 |
0 |
66.7 |
(1.7, 371) |
0.0 |
(0.3, 246 |
0.0 |
(0.0, 97.5) |
|
Lane 1969 |
288,000 |
7 |
0 |
24.3 |
(9.8, 50.1) |
0.0 |
(0.3, 12.8) |
0.0 |
(0.0, 41.0) |
|
Lane 1970 |
33,000 |
1 |
0 |
30.3 |
(0.8, 169) |
0.0 |
(0.3, 112 |
0.0 |
(0.0, 97.5) |
|
Ratner 1970b |
107,822 |
0 |
0 |
0.0 |
(0.0, 34.2) |
0.0 |
(0.3, 34.2) |
n/a |
n/a |
|
Summary |
760,822 |
10 |
0 |
13.1 |
(6.3, 24.2) |
0.0 |
(0.0, 4.8) |
0.0 |
(0.0, 30.8) |
|
All agesc |
|||||||||
|
Neff 1967a |
6,239,000 |
54 |
0 |
8.6 |
(6.5, 11.3) |
0.0 |
(0.0, 0.6) |
0.0 |
(0.0, 6.6) |
|
Neff 1967b |
298,000 |
24 |
0 |
80.5 |
(51.6, 120) |
0.0 |
(0.0, 12.4) |
0.0 |
(0.0, 14.2) |
|
Lane 1969 |
5,594,000 |
58 |
0 |
10.4 |
(7.9, 13.4) |
0.0 |
(0.0, 0.7) |
0.0 |
(0.0, 6.2) |
|
Lane 1970 |
596,000 |
25 |
0 |
41.9 |
(27.1, 61.9) |
0.0 |
(0.0, 6.2) |
0.0 |
(0.0, 13.7) |
|
Mellin 1970 |
109,000 |
5 |
0 |
45.9 |
(14.9, 107) |
0.0 |
(0.0, 33.8) |
0.0 |
(0.0, 52.2) |
|
Ratner 1970 |
369,546 |
3 |
0 |
8.1 |
(1.7, 23.7) |
0.0 |
(0.0, 10.0) |
0.0 |
(0.0, 70.8) |
|
Neff 1972 |
549 |
0 |
0 |
0.0 |
(0.0, 6697) |
0.0 |
(0.0, 6697) |
n/a |
n/a |
|
Summary |
13,206,095 |
169 |
0 |
12.8 |
(10.9, 14.9) |
0.0 |
(0.0, 0.3) |
0.0 |
(0.0, 2.2) |
|
|
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|
n/c = not calculated, n/a = not assessable aRisk and confidence intervals not calculated (n/c) for less that 100 vaccinations. Exact confidence intervals based on the binomial distribution. bThe Ratner study age groups, "Age 5 to 14" and "Age 15+", were counted in the Table age groups "Age 5 to 19" and "Age 20+", respectively. cAll ages group includes subjects whose age was unknown |
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|
Aragón et al. BMC Public Health 2003 3:26 doi:10.1186/1471-2458-3-26 |
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