Open Access Research article

Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies

Victoria Abril-Ulloa12, Gemma Flores-Mateo34, Rosa Solà-Alberich15, Begoña Manuel-y-Keenoy6 and Victoria Arija1367*

Author Affiliations

1 Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, Reus, Spain

2 Dirección de Investigación (DIUC), Universidad de Cuenca, Cuenca, Azuay, Ecuador

3 Unitat de Suport a la Recerca Tarragona-Reus, Institut Universitari d’Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Tarragona, Spain

4 CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Madrid, Spain

5 Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain

6 University of Antwerp, Antwerp, Belgium

7 Nutrition and Public Health Unit, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain

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BMC Public Health 2014, 14:483  doi:10.1186/1471-2458-14-483

Published: 21 May 2014

Abstract

Background

Elevated ferritin levels have been associated with single cardiovascular risk factors but the relationship to the presence of metabolic syndrome is inconclusive.

The aim of this systematic review and meta-analysis of published observational studies was to estimate the association between serum ferritin levels and metabolic syndrome in adults.

Methods

The Pubmed, SCOPUS and the Cochrane Library databases were searched for epidemiological studies that assessed the association between ferritin levels and metabolic syndrome and were published before September 2013. There were no language restrictions. Two investigators independently selected eligible studies. Measures of association were pooled by using an inverse-variance weighted random-effects model. The heterogeneity among studies was examined using the I2 index. Publication bias was evaluated using the funnel plot.

Results

Twelve cross-sectional, one case–control and two prospective studies met our inclusion criteria including data from a total of 56,053 participants. The pooled odds ratio (OR) for the metabolic syndrome comparing the highest and lowest category of ferritin levels was 1.73 (95% CI: 1.54, 1.95; I2 = 75,4%). Subgroup analyses indicate that pooled OR was 1.92 (95% CI: 1.61, 2.30; I2 = 78%) for studies adjusting for C-reactive protein (CRP), and 1.52 (95% CI:1. 36, 1.69; I2 = 41%) for studies that did not adjust for CRP (P = 0.044). This finding was remarkably robust in the sensitivity analysis. We did not find publication bias.

Conclusions

The meta-analysis suggests that increased ferritin levels are independently and positively associated with the presence of the metabolic syndrome with an odds ratio higher than 1.73.

Keywords:
Ferritin; Metabolic syndrome; Meta-analysis