Table 1

Characteristics of included studies

Author

Year of publication

Country

Period of Intervention

Target population

Antiemetic

Route of administration

Dose and Frequency

Duration of Follow up

Study design


Uhlig [19]

2009

Germany

December 2005 to May 2007

Children 6 months to 6 years with suspected infectious gastroenteritis (<24 hours) with mild or no dehydration, 2 vomiting in 12 hours, > 7kg

Dimenhydrinate

Rectal Suppositories

<15kg 40mg, 15 to 25 kg 80mg, >25kg 120 mg

18-24 hours after randomization, and 7-14 days after randomization

Double Blind, Prospective, Randomized, Placebo control, Multicenter

Freedman [13]

2006

USA

January 2004 to April 2005

Children 6 months to 10 years with vomiting or dehydration as a result of AGE and at least one episode of nonbilious vomiting, and no severe dehydration

Ondansetron

Oral

8-15kg 2mg, 15-30kg 4mg, >30kg 8mg

day 3 and day 7 via telephone, last follow-up till max of 2 weeks

Double Blind, Prospective Placebo

Ramsook [15]

2002

USA

Children 6 months to 12 years with clinically diagnosed AGE with 5 episodes of vomits in 24 hours

Ondansetron

Oral

6 months to 1 year 1.6mg, 1 year to 3 years 3.2mg, 4 to 12 years 4mg

24 and 48 hours

Double Blind, Prospective

Roslund [17]

2008

USA

July 1, 2004, to August 1, 2005

Children 1 to 10 years with AGE and mild to moderate dehydration who failed controlled oral challenge in ED

Ondansetron

Oral

<15kg 2mg, 15 to 23 kg 4mg, >30kg 6 mg

1 week

Double Blind, Prospective

Stork [20]

2006

USA

November 1999 and February 2005

Children aged 6 months to 12 years, with more than three episodes of vomiting in the past 24 hours, mild/moderate dehydration, and failed oral hydration. Children with a history or physical examination findings inconsistent with the diagnosis of isolated acute viral gastritis were excluded

Ondansetron or dexamethasone with IVF

IV

dexamethasone 1 mg/kg (15 mg maximum), ondansetron 0.15 mg/kg

2 hour follow-ups up to 48 hours

Double Blind, Prospective

Yilmaz [18]

2010

Turkey

August 2003 and September 2004

Children aged 5 months to 8 years who had nonbillious, nonbloody vomit at least 4 times in the last 6 hours, who could not tolerate ORT, at least four episodes of diarrhea in the previous 24 hours, and who had mild-to-moderate dehydration. Aetiology of acute gastroenteritis (viral, bacterial or amebic) was not taken into account in the patients included in the study.

Ondansetron

Oral

ondansetron 0.2 mg/ kg 8 hourly

24 hours

Double blind, Prospective

Cubeddu [12]

1997

Venezuela

6 months to 8 years with spontaneous vomiting with in 1 hour and no severe dehydration

Ondansetron, metoclopramide

IV

ondansetron 0.3 mg/kg single dose, metoclopramide 0.3 mg/kg single dose

24 hours

Double Blind, Prospective, parallel group, placebo


Das et al. BMC Public Health 2013 13(Suppl 3):S9   doi:10.1186/1471-2458-13-S3-S9

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