Table 4

Quality assessment of studies on lactose-free liquid feeds versus lactose-containing mixed diets

QUALITY ASSESSMENT

SUMMARY OF FINDINGS


Number of studies

Diarrhea mode

Design

Limitations

Consistency

Generalizability to population of interest

Overall quality of evidence

Number of events in intervention group

Number of events in control group

Effect size (95% CI)


OUTCOME: DURATION OF DIARRHEA

Standardized Mean Difference


1

Acute

RCT

Single study of high quality

-

Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs

Low

-

-

0.75 [0.22, 1.28]

1

Persistent

RCT

Single study of moderate quality

-

Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs

Low

-

-

0.28 [-0.35, 0.90]


OUTCOME: STOOL OUTPUT

Standardized Mean Difference


1

Acute

RCT

Single study of high quality

-

Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs

Low

-

-

0.62 [0.09, 1.14]

2

Persistent

RCT

Only two studies, both of moderate quality

Heterogeneous (I2= 50%)

Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs

Low

-

-

0.22 [-0.33, 0.78]


OUTCOME: WEIGHT GAIN

Standardized Mean Difference


1

Acute

RCT

Single study of high quality

-

Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs

Low

-

-

0.21 [-0.31, 0.72]

2

Persistent

RCT

Only two studies, both of moderate quality

Heterogeneous (I2= 94%)

Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs

Low

-

-

-0.35 [-2.00, 1.31]


OUTCOME: TREATMENT FAILURE

Risk Ratio


2

Acute

RCT

Only two studies, ranging from moderate to high quality

Heterogeneous (I2= 60%)

Non-malnourished infants and young children (≤24m) with acute diarrhea in LMICs

Low

7

3

1.79 [0.15, 20.66]

2

Persistent

RCT

Only two studies, both of moderate quality

Heterogeneous (I2= 72%)

Malnourished weaned infants and young children (≤36m) with persistent diarrhea in LMICs

Low

6

7

1.25 [0.07, 23.66]


Gaffey et al. BMC Public Health 2013 13(Suppl 3):S17   doi:10.1186/1471-2458-13-S3-S17

Open Data