Table 2

Quality assessment of studies on reduced lactose versus regular lactose liquid feeds

QUALITY ASSESSMENT

SUMMARY OF FINDINGS


Number of studies

Diarrhea mode

Design

Limitations

Consistency

Generalizability to population of interest

Overall quality of evidence

Number of events in intervention group

Number of events in control group

Effect size (95% CI)


OUTCOME: DURATION OF DIARRHEA

Standardized Mean Difference


4

Acute

RCT

Study quality ranges from low to high

Heterogeneous (I2= 82%)

Infants and young children (≤36m) with acute diarrhea, not severely malnourished, in LMICs

Low

-

-

-0.49 [-1.04, 0.07]

0

Persistent

RCT

No studies

-

-

-

-

-

-


OUTCOME: STOOL OUTPUT

Standardized Mean Difference


3

Acute

RCT

Study quality ranges from moderate to high

Consistent (I2= 41%)

Infants with acute diarrhea, not severely malnourished, in LMICs

Moderate

-

-

-0.18 [-0.56, 0.19]

1

Persistent

RCT

Single study of moderate quality

-

Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs

Low

-

-

-0.25 (-0.73, 0.24)


OUTCOME: WEIGHT GAIN

Standardized Mean Difference


2

Acute

RCT

Only two studies, of moderate to high quality

Consistent (I2= 0%)

Infants with acute diarrhea, not severely malnourished, in LMICs

Moderate

-

-

-0.02 [-0.29, 0.25]

1

Persistent

RCT

Single study of moderate quality

-

Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs

Low

-

-

0.39 (-0.09, 0.87)


OUTCOME: TREATMENT FAILURE

Risk Ratio


6

Acute

RCT

Study quality ranges from moderate to high; two studies report zero event counts in both groups

Consistent (I2= 0%)

Infants and young children (≤48m) with acute diarrhea, not severely malnourished, in LMICs

Moderate

30

31

1.08 [0.71, 1.64]

1

Persistent

RCT

Single study of moderate quality

-

Non-malnourished, non-breastfed infants with persistent diarrhea in LMICs

Low

4

15

0.27 [0.10, 0.74]


Gaffey et al. BMC Public Health 2013 13(Suppl 3):S17   doi:10.1186/1471-2458-13-S3-S17

Open Data