Table 4

Application of CHERG Rules for selection of point estimate for sepsis mortality for inclusion to LiST model [7]

Outcome measure


Total Events

Effect size

GRADE quality of pooled estimate

Application of standard rules

Sepsis specific neonatal mortality


Not reported

31 % reduction, statistically non-significant

(RR=0.69, 95 % CI 0.40-1.18)


Effect size for sepsis specific mortality was not used for inclusion in LiST model as results were not statistically significant and overall quality grade was “low”

All cause neonatal mortality



23% reduction, Statistically significant

(RR=0.77, 95 % CI 0.63 - 0.94)

Moderate →


Effect size for all-cause mortality was used for inclusion to LiST model. This was based on rule 1 that says that if there is no evidence for cause specific mortality and there is evidence for all-cause mortality, use the effect size for all-cause and down grade quality grade by one.

Imdad et al. BMC Public Health 2013 13(Suppl 3):S15   doi:10.1186/1471-2458-13-S3-S15

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