Table 6

Schedule for final in-clinic evaluation of smokers
Day and suggested times Sampling Procedure
181
1700 h (check in) Blood, urine Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; collection of diary and cigarette butts; dinner
1900 h None Start first 24 h urine collection, monitoring of cigarette consumption and collection of filters
2100 h None Snack
182
0700 h Blood Measure BP, PR, RR and temperature; measure creatinine in serum; biomarkers and gene expression
0800 h None Breakfast
To be scheduled None Assess smoking behavioura
1000 h None Administer sensory, quality-of-life and diet and lifestyle questionnaires†
1200 h None Lunch
1500 h None Measure exhaled CO
1700 h Saliva Cotinine testing; dinner
1900 h None End first and start second 24 h urine collection, monitoring of cigarette consumption and collection of filters
2100 h None Snack
183
Anytime (check out) None Measure BP, PR, RR and temperature; physical examination; electrocardiography
0700 h Blood Measure creatinine in serum; biomarkers
0800 h None Breakfast
To be scheduled None Assess smoking behavioura
1100 h None Pulmonary-function test
1200 h None Lunch
1500 h None Measure exhaled CO
1700 h Saliva Cotinine testing; dinner
1900 h None End second 24 h urine collection, monitoring of cigarette consumption and collection of filters; dispense adequate commercial products of normal ISO tar yield for 7 post-study days

BP, blood pressure, PR, pulse rate, RR, respiratory rate, CO, carbon monoxide, aTo be performed by sponsor. †May be done on day 183.

Shepperd et al.

Shepperd et al. BMC Public Health 2013 13:690   doi:10.1186/1471-2458-13-690

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