|Schedules for second, third and fourth in-clinic evaluations of smokers|
|Days and suggested times||Sampling||Procedure|
|45, 76, 108|
|1700 h (check in)||Blood, urine||Measure BP, PR, RR and temperature; abbreviated physical examination and medical history; illicit drug, alcohol and cotinine testing; pregnancy testing; collection of diary and cigarette butts; clinical laboratory tests; electrocardiography; lung- function tests; dinner|
|1900 h||None||Start 24 h urine collection, monitoring of cigarette consumption and collection of filters|
|46, 77, 109|
|0700 h||Blood||Measure BP, PR, RR and temperature; measure creatinine in serum; biomarkers and gene expression|
|1000 h||None||Administer sensory questionnaire; administer quality-of-life and diet and lifestyle questionnairesa|
|1500 h||None||Measure exhaled CO|
|1700 h||Saliva||Cotinine testing; dinner|
|1900 h||None||End 24 h urine collection, monitoring of cigarette consumption and collection of filters; dispense interventional products and cigarette butt collection tins for use at home, remind participants of instructions for diet and completion of diaries|
BP, blood pressure, PR, pulse rate, RR, respiratory rate, CO, carbon monoxide, aOn day 108–109 visit only; may be conducted on either day.
Shepperd et al.
Shepperd et al. BMC Public Health 2013 13:690 doi:10.1186/1471-2458-13-690