Table 2

Strong inducers or inhibitors of CYP (cytochrome P450) enzymes[19]
INHIBITORS
1A2 2B6 2C8 2C19
Cimetidine Thiotepa Gemfibrozil Fluoxetine
Fluoroquinolones Ticlopidine Montelukast Fluvoxamine
Fluvoxamine Ketoconazole
Ticlopidine Lansoprazole
Omeprazole
Ticlopidine
INHIBITORS
2C9 2D6 2E1 3A4,5,7
Amiodarone Amiodarone Disulfiram
    HIV antivirals
:
Fluconazole Bupropion Indinavir
Isoniazid Chlorpheniramine Nelfinavir
Cimetidine Ritonavir
Clomipramine Amiodarone
Duloxetine NOT azithromycin
Fluoxetine Cimetidine
Haloperidol Clarithromycin
Methadone Diltiazem
Mibefradil Erythromycin
Paroxetine Fluvoxamine
Quinidine Itraconazole
Ritonavir Ketoconazole
Doxepin Mibefradil
Nefazodone
Troleandomycin
Verapamil
INDUCERS
1A2 2B6 2C8 2C19
N/A Phenobarbital N/A N/A
Phenytoin
Rifampin
2C9 2D6 2E1 3A4,5,7
Rifampin N/A Isoniazid Carbamazepine
Secobarbital Phenobarbital
Phenytoin
Pioglitazone
Rifabutin
Rifampin
St John’s wort
Troglitazone

(Adapted with permission from Version 5.0 (http://medicine.iupui.edu/clinpharm/ddis/table.aspx webcite)).

1A2, 2B6 etc = CYP enzyme subtypes.

Shepperd et al.

Shepperd et al. BMC Public Health 2013 13:690   doi:10.1186/1471-2458-13-690

Open Data