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Open Access Research article

Association between obesity and atopic disorders in Chinese adults: an individually matched case–control study

Xiao Luo1, Jing Xiang1, Xiaohui Dong1, Fuwen Cai1, Jianing Suo1, Zhiqiang Wang2* and Meina Liu1*

Author Affiliations

1 Public Health College, Harbin Medical University, 157 Baojian Road, Haerbin City, Heilongjiang Province, Postcode 150081, People's Republic of China

2 School of Medicine, the University of Queensland, Room 817, Health Sciences Building, Royal Brisbane & Women’s Hospital, Herston, QLD 4029, Australia

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BMC Public Health 2013, 13:12  doi:10.1186/1471-2458-13-12

Published: 8 January 2013

Abstract

Background

Obesity is regarded as a potential risk factor for atopy. The aim of this study was to assess the associations of obesity with atopic dermatitis, rhinitis, asthma and food allergy in Chinese adults.

Methods

Two hundred and sixty six (266) atopic cases in Harbin, China, were identified according to the current Chinese guidelines for the diagnosis of atopic diseases. All cases had a previous diagnosis of atopic disorders (atopic dermatitis, rhinitis, asthma or food allergy) and were positive in one or more allergen specific IgE tests to 16 common allergens in the region. Each case was individually matched to two healthy controls based on their age, sex, and residential regions. All 532 healthy controls were negative in allergen specific IgE tests. The associations of obesity with four atopic disorders were assessed using a conditional logistic regression method.

Results

Obesity was significantly associated with the presence of atopic diseases (OR = 3.2, 95% CI: 1.8, 5.7). Males and females had a similar association (OR = 3.1 for males and 3.2 for females). The associations of obesity with atopic dermatitis (OR = 2.7, 95% CI: 1.2, 6.3) and atopic rhinitis (OR = 3.1, 95% CI: 1.1, 8.7) were statistically significant. Although obesity was positively associated with atopic asthma, this association was not statistically significant (OR = 3.4, 95% CI: 0.6, 19.9). The association between obesity and food allergy was weak and not significant (OR = 1.1, 95% CI: 0.4, 3.7).

Conclusions

Obesity is positively associated with the presence of atopic diseases in Chinese adults. Specifically, obesity is significantly associated with atopic dermatitis and rhinitis. Our findings warrant further investigation on the causal nature between obesity and atopic diseases and the effect of weight reduction on preventing atopic diseases.