Table 2

Incidence and Risk of hospitalization for community acquired pneumonia (CAP), acute myocardial infarction (AMI), ischaemic stroke and death from any cause among patients 60 years or older in relation to pneumococcal-vaccination statusa

CAP

AMI

Ischaemic Stroke

Death from

any cause


Number of event

Vaccinated

63

41

30

231

Unvaccinated

144

89

91

609


Unadjusted incidence rate per 1000 person-years

Vaccinated

7.1 (5.6-9.1)

4.6 (3.4-6.3)

3.4 (2.4-4.9)

26.1 (23.0-29.7)

Unvaccinated

8.2 (7.0-9.7)

5.1 (4.1-6.2)

5.2 (4.2-6.4)

34.6 (32.0-37.5)


Unadjusted hazard ratio for all subjects

0.87

0.91

0.66

0.75

(95% CI)

(0.65-1.17)

(0.63-1.32)

(0.43-0.99)

(0.65-0.88)

p value

0.368

0.637

0.046

< 0.001


Age, gender adjusted hazard ratio

0.87

0.90

0.66

0.79

(95% CI)

(0.65-1.17)

(0.62-1.30)

(0.44-1.00)

(0.68-0.91)

p value

0.354

0.582

0.049

0.002


b

c

d

e

Multivariate hazard ratio

0.85

0.83

0.65

0.88

(95% CI)

(0.62-1.15)

(0.56-1.22)

(0.42-0.99)

(0.75-1.03)

p value

0.287

0.347

0.048

0.118


a Hazard ratios were for vaccinated subjects as compared with unvaccinated subjects.

b Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, chronic pulmonary disease, chronic heart disease, smoking and nursing-home resident.

c Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, history of coronary artery disease, chronic heart disease, diabetes mellitus, hypercholesterolemia, smoking (confounder) and nursing-home resident.

d Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, history of coronary artery disease, history of stroke, smoking (confounder) and nursing-home resident.

e Adjusted for age, sex, number of outpatient visits in prior year, influenza vaccination in prior year, chronic pulmonary disease, chronic heart disease, diabetes mellitus, cancer, chronic nephropaty, dementia, hypertension, hypercholesterolemia, obesity, smoking, and nursing home-resident.

Vila-Corcoles et al. BMC Public Health 2012 12:222   doi:10.1186/1471-2458-12-222

Open Data