Table 1

Quality assessment of trials of iron and/or folate on the incidence of anemia during pregnancy

Quality Assessment

Summary of Findings


No of studies (ref)

Design

Limitations

Consistency

Directness

No of events


Generalizability to population of interest

Generalizability to intervention of interest

Intervention

Control

Relative Risk (95% CI)


Daily iron versus no intervention/placebo Anemia at term: Moderate outcome specific quality


14

RCT/quasi RCT

Studies with unclear or inadequate sequence generation and high loss to follow-up

All studies show direction of benefit, but high heterogeneity

Only two studies in developing countries, rest in developed nations

Yes

114

313

RR (random) = 0.27 [ 0.17, 0.42 ]


Daily iron versus no intervention/placebo: Iron deficiency anemia at term: Moderate outcome specific quality


6

RCT/quasi RCT

Studies with unclear or inadequate sequence generation and high loss to follow-up

All studies show direction of benefit, with borderline heterogeneity

Only one study in developing country, rest in developed

Yes

25

68

RR (random) = 0.33 [ 0.16, 0.69 ]


Daily iron and folic acid versus no intervention/placebo: Anemia at term: Moderate outcome specific quality


3

RCT/quasi-RCTs

High loss to follow-up and unclear sequence generation

Two studies show direction of benefit; while the third study had zero events

Only one study in developing country, rest in developed

Yes

17

49

RR (random) = 0.27 [ 0.12, 0.56 ]


Daily iron and folic acid versus no intervention/placebo: Iron deficiency anemia at term: Low outcome specific quality


1

RCT

Allocation concealment unclear and blinding inadequate

One study only

In a developed country

Yes

12

5

RR (random) = 0.43 [0.17, 1.09]


Yakoob and Bhutta BMC Public Health 2011 11(Suppl 3):S21   doi:10.1186/1471-2458-11-S3-S21

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