Table 1

Results of pooled analysis and qualitative grading according to GRADE criteria for outcomes of interest for inclusion in the LiST:

Quality Assessment

Summary of Findings


Directness

No of patients

Effect


No of studies

Design

Limitations

Consistency

Generalizability to Population of Interest

Generalizability to Intervention of interest

Intervention

Control

Relative Risk (95% CI)


Impact of balance protein energy supplementation on small for gestational age: Quality of evidence - Moderate


6[28,30-32,35,37]

RCTs / Cluster RCT/ Quasi RCTs

Two studies were quasi experimental trial. Sequence generation and allocation concealment was not adequate in some of the included studies.

No heterogeneity in the pooled data (I2 =0%). p= 0.65

Studies conducted in both developed and developing countries.

Protein content of Supplement for intervention group ranged from 30 g to 44 g per day. The protein content provided < 25 % of total energy content.

142

193

0.69 (0.56-0.85)


Impact of balance protein energy supplementation on neonatal mortality: Quality of evidence - Low


3[30,37,41]

RCTs/ Cluster RCT/ Quasi RCTs

One quasi-experimental design. Allocation concealment was not adequate for one of the included cluster randomized controlled trial. Large loss to follow up in included studies.

No heterogeneity. (I2 =0) p=0.81

One study from developed country and two from developing countries

Protein content of Supplement for intervention group ranged from 30 g to 44 g per day. The protein content provided < 25 % of total energy content.

23

33

0.63 (0.37-1.06)


Imdad and Bhutta BMC Public Health 2011 11(Suppl 3):S17   doi:10.1186/1471-2458-11-S3-S17

Open Data