Table 6

Application of standardized rules for choice of final outcome to estimate effect of breastfeeding on the reduction of diarrhea mortality

Outcome Measures

Application of Standard Rules


0-5 months*

Diarrhea Incidence

n=3; 1594 events

The risk of incident diarrhea is 1.26 (0.81-1.95) for predominant BF; 1.68 (1.03-2.76) for partial BF; 2.65 (1.72-4.07) for not BF as compared to EBF

Rule 2: APPLY

Diarrhea Mortality

n=2; 80 events

The risk of diarrhea mortality is 2.28 (0.85-6.13) for predominant BF; 4.62 (1.81-11.76) for partial BF; 10.52 (2.79-39.6) for not BF as compared to EBF


6-11 months

Diarrhea Incidence

n=2; 646 events

The risk of incident diarrhea is 1.32 (1.06-1.63) for not BF as compared to any BF

Rule 2: APPLY

Diarrhea Mortality

n=2; 84 events

The risk of diarrhea mortality is 1.47 (0.67-3.25) for not BF as compared to any BF


12-23 months

Diarrhea Incidence

n=0; use estimate for 6-11 mos: n=2; 646 events

The risk of incident diarrhea is 1.32 (1.06-1.63) for not BF as compared to any BF

Rule 2: APPLY

Diarrhea Mortality

n=2; 84 events

The risk of diarrhea mortality is 2.57 (1.10-6.01) for not BF as compared to any BF


*Evaluating events for studies where reference category is EBF

Lamberti et al. BMC Public Health 2011 11(Suppl 3):S15   doi:10.1186/1471-2458-11-S3-S15

Open Data