Table 1 

Kinetic parameters for influenza obtained from both fitting mathematical models to data and by direct estimation from experimental data. 

Parameter 
Values [References] 


Mathematical models to fit experimental data 



Average lifespan of an infected cell 
39h [42], 6h and 11.4h [15], 18h and 48h [39], 6h–14h [47], 17h and 40h [31], 1.8h and 33h [45] 28h. 
Average infectious lifespan of a virion 
111h [42], 4.6h and 8h [15], 8h and 300h [39], 9.5h [47], 1.8h–9.1h [45], 5.7h and 2.6min [31] 
Length of the latent (eclipse) phase 

Rate of epithelial cell (re)growth per day 

Drug efficacy 
0.97 and 0.99 [39] (oseltamivir), 0.56–0.92 [47] (amantadine) 
Lifespan of interferon 



Direct experimental measures 



Average lifespan of an infected cell 

Average infectious lifespan of a virion 

Length of the latent (eclipse) phase 



Lifespan is defined as the inverse of the rate parameters (the sometimes alternatively used halflife contains an extra factor of log(2)). Note that some of the studies are in vitro and some in vivo. Multiple values come from either differences in strains or different models analyzed within a single study. Caveats about the reliability of the estimates obtained from model fitting are discussed in the section titled “Data diversity and quantity and its effect on parameter identifiability”. 

Beauchemin and Handel BMC Public Health 2011 11(Suppl 1):S7 doi:10.1186/1471245811S1S7 