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Open Access Research article

Rapid assessment of Hib disease burden in Vietnam

Batmunkh Nyambat1*, Duc Anh Dang2, Hien Anh Nguyen2, Trinh Quynh Mai2, Manju Rani3, Mary PE Slack4 and Paul E Kilgore1

Author Affiliations

1 Division of Translational Research, International Vaccine Institute, Seoul, South Korea

2 National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

3 Expanded Programme on Immunization (EPI), Western Pacific Regional Office, World Health Organization, Manila, Philippines

4 Haemophilus Reference Unit, Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, Colindale, London, UK

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BMC Public Health 2011, 11:260  doi:10.1186/1471-2458-11-260

Published: 25 April 2011

Abstract

Background

Several countries have applied the Haemophilus influenzae type b (Hib) rapid assessment tool (RAT) to estimate the burden of Hib disease where resources for hospital- or population-based surveillance are limited. In Vietnam, we used the Hib RAT to estimate the burden of Hib pneumonia and meningitis prior to Hib vaccine introduction.

Methods

Laboratory, hospitalization and mortality data were collected for the period January 2004 through December 2005 from five representative hospitals. Based on the WHO Hib RAT protocol, standardized MS Excel spreadsheets were completed to generate meningitis and pneumonia case and death figures.

Results

We found 35 to 77 Hib meningitis deaths and 441 to 957 Hib pneumonia deaths among children < 5 years of age annually in Vietnam. Overall, the incidence of Hib meningitis was estimated at 18/100,000 (95% confidence interval, CI, 15.1-21.6). The estimated Hib meningitis incidence in children < 5 years age was higher in Ho Chi Minh City (22.5/100,000 [95% CI, 18.4-27.5]) compared to Hanoi (9.8/100,000 [95% CI, 6.5-14.8]). The Hib RAT suggests that there are a total of 883 to 1,915 cases of Hib meningitis and 4,414 to 9,574 cases of Hib pneumonia per year in Vietnam.

Conclusions

In Hanoi, the estimated incidence of Hib meningitis for children < 5 years of age was similar to that described in previous population-based studies of Hib meningitis conducted from 1999 through 2002. Results from the Hib RAT suggest that there is a substantial, yet unmeasured, disease burden associated with Hib pneumonia in Vietnamese children.

Keywords:
Hib; vaccine; RAT; disease burden