Table 2

Risk factors for relapse, failure, or default from initial TB treatment, a subgroup analysis.

Subgroup

Risk factor

Univariate analysis

(OR, 95% CI)

Multivariate analysis

(OR, 95% CI)

Relapse (N = 35)

Lack of sputum smear conversion to negative by 3 months

4.58 (2.22-9.43)

4.14 (1.92-9.01)

Missed doses during the intensive phase

3.23 (0.96-10.9)

NS

Treatment failure (N = 18)

Lack of sputum smear conversion to negative by 3 months

**

**

Comorbid conditions

3.29 (1.08-9.99)

NS

Treatment default (N = 27)

Male gender

6.50 (1.51-28.1)

4.56 (0.96-20.7)

Substance use†

4.19 (1.83-9.56)

2.73 (1.04-7.15)

Missed doses during the intensive phase

12.9 (4.65-35.7)

10.9 (3.47-34.0)

Hospitalization during treatment

2.56 (1.04-6.23)

3.84 (1.41-10.5)

** Three-month sputum smear conversion to negative was negative in all failure patients so could not be included in logistic regression models.

†Tobacco, alcohol, or illicit drug use.

Dooley et al. BMC Public Health 2011 11:140   doi:10.1186/1471-2458-11-140