Table 1

Serological parameters used in the study for data collection


WHO serological criteria [3]

Additional criteria and relevance

Hepatitis A

IgM anti-HAV positive (acute)


Hepatitis B

HBsAg positive (unspecified) or IgM anti-HBc positive (acute)

Total anti-HBc positive when IgM Anti-HBc not tested

HBV-DNA positive

Hepatitis C

anti-HCV positive (acute and unspecified combined)

HCV-confirmation positive

HCV-RNA positive, showing also infectivity


Brucella agglutination titre (e.g., standard tube agglutination > 160) or ELISA (IgA, IgG, IgM), 2-ME (confirmed)

Rose-Bengal test, due to its use as a screening test (probable)


RPR or VDRL confirmed by TPHA or FTA



Specific IgM antibodies


HIV infection

HIV positive serology (ELISA), confirmation

HIV-RNA positive

a For brucellosis, complement fixation, FAT and RIA for detecting antilipopolysaccharide antibodies also exist among WHO criteria but as these tests were not being performed in any laboratory in Izmir, they are not used as criteria.

b For measles, "at least a fourfold increase in antibody titre and virus isolation" is also stated among WHO criteria. But as it would not be practical to follow-up the first criteria and as virus isolation was not performed in any laboratory in Izmir, these criteria were not used.

Durusoy and Karababa BMC Public Health 2010 10:71   doi:10.1186/1471-2458-10-71

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