Table 6 |
||||||||
|
Results of the sensitivity analyses |
||||||||
|
Number of events avoided |
RVGE costs avoided (M€) |
|||||||
|
RVGE cases (seeking or nor medical care) |
Hospitali-zations |
Nosocomial infections |
Emergency visits |
PCC visits |
Work Days Lost |
NHS perspec-tive |
Societal perspec-tive |
|
|
|
||||||||
|
BASE CASE |
136,190 |
10,987 |
2,053 |
34,287 |
35,187 |
161,495 |
21.77 |
38.19 |
|
SENSITIVITY ANALYSES |
||||||||
|
Vaccine coverage rate |
||||||||
|
50% |
75,670 |
6,104 |
1,141 |
19,049 |
19,548 |
89,719 |
12.09 |
21.20 |
|
97% |
146,800 |
11,841 |
2,213 |
36,954 |
37,924 |
174,055 |
23.47 |
41.16 |
|
Ratio not seeking medical care/seeking medical care |
||||||||
|
-20% |
125,468 |
10,987 |
2,053 |
34,287 |
35,187 |
158,836 |
21.77 |
37.95 |
|
+20% |
146,945 |
10,987 |
2,053 |
34,287 |
35,187 |
164,415 |
21.77 |
38.43 |
|
Cost and benefit discount rates |
||||||||
|
0%; 0% |
136,207 |
10,987 |
2,053 |
34,287 |
35,187 |
169,052 |
22.84 |
40.02 |
|
6%; 6% |
136,207 |
10,987 |
2,053 |
34,287 |
35,187 |
154,371 |
20.77 |
36.46 |
|
Incidences |
||||||||
|
PCC |
||||||||
|
-20% |
124,197 |
10,987 |
2,053 |
34,287 |
28,150 |
151,082 |
21.66 |
36.96 |
|
+20% |
148,216 |
10,987 |
2,053 |
34,287 |
42,225 |
171,908 |
21.88 |
39.41 |
|
Hospitalization |
||||||||
|
-20% |
132,534 |
8,789 |
2,053 |
34,287 |
35,187 |
154,633 |
19.17 |
34.92 |
|
+20% |
139,880 |
13,184 |
2,053 |
34,287 |
35,187 |
168,357 |
24.37 |
41.45 |
|
Emergency visits |
||||||||
|
-20% |
125,058 |
10,987 |
2,053 |
27,430 |
35,187 |
147,119 |
20.43 |
35.40 |
|
+20% |
147,355 |
10,987 |
2,053 |
41,145 |
35,187 |
175,870 |
23.12 |
40.98 |
|
Nosocomial infections |
||||||||
|
-20% |
135,796 |
10,987 |
1,642 |
34,287 |
35,187 |
160,846 |
21.48 |
37.83 |
|
+20% |
136,617 |
10,987 |
2,464 |
34,287 |
35,187 |
162,143 |
22.07 |
38.55 |
|
Vaccine efficacy in reduction of RVGE cases (95% CI) |
||||||||
|
90.5%: hospitalizations, NI 88.8%: emergency visits 73.9%: PCC and home care |
121,187 |
10,379 |
1,939 |
32,494 |
30,236 |
147,707 |
20.54 |
35.54 |
|
98.2%: hospitalizations, NI 96.5%: emergency visits 92.5%: PCC and home care |
144,258 |
11,262 |
2,104 |
35,312 |
37,847 |
168,854 |
22.39 |
39.55 |
|
Vaccine efficacy annual rate by age |
||||||||
|
10% decrease in year 2 and exponential decrease until year 4. |
135.507 |
10,891 |
2,051 |
34,208 |
34,987 |
160,770 |
21.65 |
37.99 |
|
NHS & Societal costs (95% CI) |
||||||||
|
Lower values |
136,1901 |
10,987 |
2,053 |
34,287 |
35,187 |
161,4951 |
19.59 |
33.57 |
|
Higher values |
36,190 |
10,987 |
2,053 |
34,287 |
35,187 |
61,495 |
23.94 |
44.64 |
|
|
||||||||
|
Diez-Domingo et al. BMC Public Health 2010 10:469 doi:10.1186/1471-2458-10-469 |
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