Open Access Study protocol

Effectiveness of hygienic-dietary recommendations as enhancers of antidepressant treatment in patients with Depression: Study protocol of a randomized controlled trial

Mauro Garcia-Toro12*, Olga Ibarra13, Margalida Gili14, Joan Salva13, Saray Monzón14, Margalida Vives14, Maria J Serrano14, Javier Garcia-Campayo5 and Miquel Roca14

Author Affiliations

1 Institut Universitari d'Investigació en Ciències de la Salut (IUNICS). Universitat de les Illes Balears (UIB). Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP). Spain

2 Department of Psychiatry. Hospital Son Llatzer. Palma de Mallorca. Spain

3 Department of Psychiatry. Hospital Son Dureta. Palma de Mallorca. Spain

4 Department of Psychiatry. Hospital Joan March. Palma de Mallorca. Spain

5 Department of Psychiatry, Hospital Miguel Servet, Universidad de Zaragoza, Zaragoza, Red de Investigación en Actividades Preventivas y Promoción de la Salud (redIAPP). Spain

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BMC Public Health 2010, 10:404  doi:10.1186/1471-2458-10-404

Published: 9 July 2010



In recent years some studies have been published supporting the efficacy of light exposure, physical activity, sleep control and a Mediterranean diet pattern on the improvement or prevention of Depression. However, to our knowledge, there have been no studies using all these measures together as an adjuvant antidepressant strategy.


Multicenter, randomized, controlled, two arm-parallel, clinical trial. Eighty depressed patients undergoing standard antidepressant treatment will be advised to follow four additional hygienic-dietary recommendations about exercise, diet, sunlight exposure and sleep. Outcome measures will be assessed before and after the 6 month intervention period.


We expect the patients in the active recommendations group to experience a greater improvement in their depressive symptoms. If so, this would be a great support for doctors who might systematically recommend these simple and costless measures, especially in primary care.

Trial Registration