Table 1

Model input parameters and outputs

Parameter

Meaning

Notes on values; (allowable ranges)


Inputs


Λ

TB incidence rate (new cases)

Fixed incidence (value irrelevant)


kFN

Fraction of new cases that go to the public sector

(0-1)


kRN

Fraction of retreatment cases that go to the public sector

(0-1)


yt

Fraction of new cases that are sensitive

1-qC Where q is the relative transmissibility of resistant compared with sensitive strains (range of q from 0-1; assumes no resistant "superbugs") and C (range of C from 0-1) is the proportion of all incident cases with MDR


xS

Fraction of new sensitive cases that go to the public sector

(0-1)


xR

Fraction of new resistant cases that go to the public sector

(0-1)


fR, fS

f•N, f•P

Fraction failing treatment among drug resistant and sensitive

Fraction failing treatment in public and private sectors

fS fR Failure more likely for resistant

and

f•N f•P Failure as or more likely in private sector


aN,aP

Fraction of TB cases in the public and private sectors who acquire resistance

(0-1) aN aP Acquired resistance as or more likely in private sector


l

Fraction that are lost to follow-up or die

(0-1)


rN

Fraction in the public sector that return to the public sector for next treatment episode

Retreatment cases more likely to present in public sector


rP

Fraction in the private sector that return to the private sector for next treatment episode

Retreatment cases more likely to present in public sector


Outputs


A

Proportion of new cases with resistant TB


AN

Proportion of new cases in public sector with resistant TB


AP

Proportion of new cases in private sector with resistant TB


B

Proportion of retreatment cases with resistant TB


BN

Proportion of retreatment cases in public sector with resistant TB


BP

Proportion of retreatment cases in private sector with resistant TB


C

Proportion of all cases with resistant TB


CN

Proportion of all cases in public sector with resistant TB


CP

Proportion of all cases in private sector with resistant TB


Cohen et al. BMC Public Health 2010 10:355   doi:10.1186/1471-2458-10-355

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