Email updates

Keep up to date with the latest news and content from BMC Public Health and BioMed Central.

Open Access Research article

Pulmonary impairment after tuberculosis and its contribution to TB burden

Jotam G Pasipanodya25*, Scott JN McNabb3, Peter Hilsenrath6, Sejong Bae1, Kristine Lykens1, Edgar Vecino2, Guadalupe Munguia2, Thaddeus L Miller12, Gerry Drewyer4 and Stephen E Weis124

Author affiliations

1 School of Public Health, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA

2 Department of Medicine, University of North Texas Health Science Center at Fort Worth, Fort Worth, Texas, USA

3 Centers for Disease Control and Prevention, Atlanta, GA, USA

4 Tarrant County Public Health Department, Fort Worth, Texas, USA

5 Division of Infectious Diseases, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390-9113, USA

6 Eberhardt School of Business and Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, California, 95211, USA

For all author emails, please log on.

Citation and License

BMC Public Health 2010, 10:259  doi:10.1186/1471-2458-10-259

Published: 19 May 2010

Abstract

Background

The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs).

Methods

TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis.

Results

There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability-chronic.

Conclusions

Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.