Table 3

Course of the illness over 24 months.

Pure Mania

Mixed episode


Over 24 months

n = 364

Over 24 months

n = 164


Course:

→ Relapse(1) (%, IC95%)

53% [49%, 58%]

57% [50%, 63%]

→ Recurrence (2) (%, IC95%)

12% [9%, 16%]

19% [13%, 26%]

→ Remission (3) (%, IC95%)

61% [56%, 66%]

62% [55%, 69%]

→ Recovery (4) (%, IC95%)

46%* [41%, 51%]

36%* [30%, 42%]


Percentages are based on the Survival distribution (Kaplan-Meier estimations).

(1) Relapse:

    - Maintenance phase (24 months) only
: Patients not achieving remission and if the patient meets one of the 3 following relapse criteria:

- Increase in CGI-BP Total since the last visit, with a score of 4 or more

- Admission to hospital for an acute episode of bipolar disorder

- Psychiatrist's opinion, the patient has experienced a relapse since the last interview

(2) Recurrence:

    - Maintenance phase (24 months) only
: If the patient is in remission and then met one of the three previous relapse criteria.

(3) Remission:

    Maintenance phase (24 months) only
: patient with a CGI-BP Overall under 3 for 2 consecutive visits with no relapse between the visits. If the patient is lost to follow-up, the remission is considered as a missing data.

(4) Recovery:

    - Maintenance phase (24 months)
: Patient is in functional remission (remission and not dissatisfied with life) and social functioning is adequate (i.e. no work impairment, independent accommodation and at least 4 social activities in the previous 4 weeks OR with a partner (live-in or not live-in)).

* = There is a significant difference between the Pure Mania and mixed episode patient groups, with a risk α = 0.05.

Azorin et al. BMC Psychiatry 2009 9:33   doi:10.1186/1471-244X-9-33

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