|Definitions and criteria for post hoc analysis of clinical response and symptomatic remission[12,18]|
|Terms||Definitions and Criteria|
|Clinical response||≥30% reduction in ADHD-RS-IV with adult prompts total scorea and a CGI-I rating of 1 or 2|
|Symptomatic remission||ADHD-RS-IV total score ≤18 (average per-item score ≤1)|
|Time to median clinical response or symptomatic remission||Time by which half the original sample achieves criteria for clinical response or symptomatic remission|
|Loss of clinical response or symptomatic remission status||Failure to meet criteria for clinical response or symptomatic remission after having achieved that status at a previous visit|
|Maintenance of clinical response or symptomatic remission at endpoint||4-week trial:|
|Participants meeting criteria for clinical response or symptomatic remission at postbaseline visits, enrolled at endpoint, and meeting criteria without interruption|
|Participants meeting criteria for clinical response or symptomatic remission at postbaseline visits and meeting the criteria without interruption up to endpoint|
aRelative to baseline ADHD-RS-IV total score in the 4-week trial.
Abbreviations: ADHD-RS-IV = Attention-Deficit/Hyperactivity Disorder Rating Scale IV; CGI-I=Clinical Global Impressions-Improvement.
Mattingly et al.
Mattingly et al. BMC Psychiatry 2013 13:39 doi:10.1186/1471-244X-13-39