Table 1

Demographic details of cases used in this study
Control group Bipolar disorder group Schizophrenia group
(n = 35) (n = 34) (n = 35)
Diagnostic subtype - BP1 = 27, BP2 = 4, BPNOS = 2, schizoaffective = 1 SCZ(disorganised) = 1, SCZ(paranoid) = 8, SCZ(undifferentiated) = 26
Age (years) 44.2 (31–60) 45.4 (19–64) 42.6 (19–59)
Gender 9 F, 26 M 18 F, 16 M 9 F, 26 M
Hemisphere 16 L, 19R 19 L, 15R 17 L, 18R
pH 6.61 +/− 0.27 6.43 +/− 0.30 6.48 +/− 0.24
PMI (hours) 29.4 +/− 12.9 37.9 +/− 18.6 31.4 +/− 15.5
RIN 7.23 +/− 0.87 7.34 +/− 0.88 7.36 +/− 0.61
Manner of death natural = 35 natural = 19, suicide = 15 natural = 28, suicide = 7
Age of onset (years) - 25.3 +/− 9.2 21.3 +/− 6.1
Duration of illness (years) - 20.2 +/− 9.6 21.3 +/− 10.2
Lifetime antipsychotics (fluphenazine equivalents, mg) - 10212 +/−22871 85004 +/− 100335
Antidepressant use yes = 0, no = 35 yes = 19, no = 15 yes = 9, no = 26
Type of antidepressant* - SSRI = 9 (fluoxetine = 5) SNRI = 4, SARI = 5, TCA = 6, other = 1 SSRI = 4 (fluoxetine = 2), SNRI = 0, SARI = 2, TCA = 2, other = 2
Smoking around time of death yes = 9, no = 9, unknown = 17 yes = 15, no = 6, unknown = 13 yes = 23, no = 4, unknown = 8

Demographic details of controls, bipolar disorder cases and schizophrenia cases used in this study. *Note- some individuals took multiple antidepressant medications. Abbreviations: BP1 = bipolar disorder type I, BP2 = bipolar disorder type II, BPNOS = bipolar disorder not otherwise specified, SCZ = schizophrenia, M = male, F = female, L = left, R = right, PMI = post-mortem interval, RIN = RNA integrity number, SSRI = selective serotonin reuptake inhibitor, SNRI = serotonin–norepinephrine reuptake inhibitor, SARI = serotonin antagonist and reuptake inhibitor, TCA = tricyclic antidepressant. Data quoted are mean (range) +/− standard deviation.

Sinclair et al.

Sinclair et al. BMC Psychiatry 2012 12:84   doi:10.1186/1471-244X-12-84

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