Table 3

Linear correlations of demographics and clinical variables to patient anterior insula GMV
Demographic/clinical variable Left anterior insula Right anterior insula
Predicted IQ r(117) = .03 r(117) = −.01
Age of onset of illness r(124) = −.02 r(124) = −.04
Years of Education r(125) = −.10 r(125) = −.05
Antidepressant dose (mg/day) r(110) = .09 r(110) = .02
Antipsychotic dose (mg/day) r(110) = −.04 r(110) = −.10
Mood stabiliser dose (mg/day) r(110) = .03 r(110) = .04
Social and occupational functioning (SOFAS) r(119) = −.12 r(119) = −.11
Psychological distress (K-10) r(125) = .08 r(125) = .06
Depression (HDRS) r(121) = .10 r(121) = −.04
Depression (DASS Depression subscore) r(116) = .11 r(116) = .00
Anxiety (DASS Anxiety subscore) r(116) = −.01 r(116) = −.03
Stress (DASS Stress subscore) r(116) = .08 r(116) = .03
Social interaction anxiety (SIAS) r(122) = .18* r(122) = .23**
Symptom severity (BPRS Total) r(116) = .12 r(116) = .03
Positive symptoms (BPRS Positive Symptoms subscore) r(116) = .10 r(116) = .10
Negative symptoms (BPRS Negative Symptoms subscore) r(116) = .12 r(116) = .02
Depression (BPRS Depression subscore) r(116) = .01 r(116) = −.09
Mania (BPRS Mania subscore) r(116) = .08 r(116) = .06

Pearson partial correlations explored the linear correlations between the left or right anterior insula GMV (corrected for ICV) with patient demographic and clinical variables (n = 133) controlling for age. *p < .05; **p < .01 (2-tailed).

Hatton et al.

Hatton et al. BMC Psychiatry 2012 12:45   doi:10.1186/1471-244X-12-45

Open Data