Table 4

The impact on clinical outcomes of switching to risperidone, compared with switching to olanzapine
Estimate 95% confidence interval P-values
Cox regression Hazard ratioa
Medication switch 1.44 0.97, 2.12 0.070
Relapse 3.43 1.43, 8.26 0.006
Linear regression Coefficientb
Change in CGI-SCH overall score before and after switching 0.29 0.06, 0.52 0.013
Change in weight (kg) before and after switching 0.22 −1.37, 1.81 0.785
Logistic regression Odds ratioc
EPS 4.02 1.49, 10.89 0.006
Loss of Libido 1.77 0.93, 3.37 0.083
Impotence/sexual dysfunction 1.93 0.95, 3.94 0.070
Amenorrhea/galactorrhea 8.99 2.30, 35.13 0.002

aA hazard ratio of more than 1 indicates an increased risk of medication switch or relapse, compared with patients switched to olanzapine.

bLinear regression modeled a change in CGI-SCH overall score (or weight) before and after switching. Coefficients indicate an estimated difference in the change, compared with patients switched to olanzapine.

cAn odds ratio of more than 1 indicates an increased likelihood of having tolerability outcomes compared with patients switched to olanzapine.

Hong et al.

Hong et al. BMC Psychiatry 2012 12:218   doi:10.1186/1471-244X-12-218

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