|The impact on clinical outcomes of switching to risperidone, compared with switching to olanzapine|
|Estimate||95% confidence interval||P-values|
|Cox regression||Hazard ratioa|
|Medication switch||1.44||0.97, 2.12||0.070|
|Change in CGI-SCH overall score before and after switching||0.29||0.06, 0.52||0.013|
|Change in weight (kg) before and after switching||0.22||−1.37, 1.81||0.785|
|Logistic regression||Odds ratioc|
|Loss of Libido||1.77||0.93, 3.37||0.083|
|Impotence/sexual dysfunction||1.93||0.95, 3.94||0.070|
aA hazard ratio of more than 1 indicates an increased risk of medication switch or relapse, compared with patients switched to olanzapine.
bLinear regression modeled a change in CGI-SCH overall score (or weight) before and after switching. Coefficients indicate an estimated difference in the change, compared with patients switched to olanzapine.
cAn odds ratio of more than 1 indicates an increased likelihood of having tolerability outcomes compared with patients switched to olanzapine.
Hong et al.
Hong et al. BMC Psychiatry 2012 12:218 doi:10.1186/1471-244X-12-218