Antioxidant defense system and family environment in adolescents with family history of psychosis
1 Stanley Institute International Mood Disorders Research Center, University of the Basque Country. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), 03-RC-003, Hospital Santiago, Vitoria, Spain
2 Adolescent Unit, Department of Psychiatry. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Hospital General Universitario Gregorio Marañon, Madrid, Spain
3 Department of Child and Adolescent Psychiatry and Psychology, IDIBAPS. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Hospital Clinic Universitari, Barcelona, Spain
4 Child and Adolescent Psychiatry Unit, Department of Psychiatry, Hospital Universitario Valdecilla, Santander, Cantabria, Spain
5 Section of Child and Adolescent Psychiatry and Psychology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
6 Child and Adolescent Psychiatry Unit, Department of Psychiatry and Medical Psychology, University of Navarra, Pamplona, Spain
7 Departamento de Farmacología, Facultad de Medicina. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universidad Complutense de Madrid, Madrid, Spain
8 Department of Neuroscience, Pharmacology and Psychiatry, School of Medicine. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), University of Cádiz, Cádiz, Spain
9 Unidad de Investigación en Psiquiatría, Hospital Santiago Apóstol Pabellón B, 8ª planta Olaguibel 29, Vitoria, Alava, 01004, SPAIN
BMC Psychiatry 2012, 12:200 doi:10.1186/1471-244X-12-200Published: 16 November 2012
Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP), and to assess its relationship with familiar environment measured using the Family Environment Scale (FES).
We included 82 HC and 14 HC-FHP aged between 9 and 17 years. Total antioxidant status, lipid peroxidation, antioxidant enzyme activities and glutathione levels were determined in blood samples.
There was a significant decrease in the total antioxidant level in the HC-FHP group compared with the HC group (OR = 2.94; p = 0.009), but no between-group differences in the Global Assessment of Functioning (GAF) scale scores. For the FES, the HC-FHP group had significantly higher scores in the cohesion (p = 0.007) and intellectual-cultural dimensions (p=0.025). After adjusting for these two FES dimensions, total antioxidant status remained significantly different between groups (OR = 10.86, p = 0.009).
Although causal relationships cannot be assumed, we can state that family environment is not playing a role in inducing oxidative stress in these healthy subjects. It could be hypothesized that families with affected relatives protect themselves from psychosis with positive environmental factors such as cohesion and intellectual-cultural activities.