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Open Access Research article

The potential role of appetite in predicting weight changes during treatment with olanzapine

Michael Case1*, Tamas Treuer2, Jamie Karagianis3 and Vicki Poole Hoffmann1

Author Affiliations

1 Lilly USA, LLC, Indianapolis, IN, USA

2 Eli Lilly & Company, Budapest, Hungary, EU

3 Eli Lilly Canada Inc., Toronto, Ontario, Canada and Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada

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BMC Psychiatry 2010, 10:72  doi:10.1186/1471-244X-10-72

Published: 14 September 2010

Abstract

Background

Clinically significant weight gain has been reported during treatment with atypical antipsychotics. It has been suggested that weight changes in patients treated with olanzapine may be associated with increased appetite.

Methods

Data were used from adult patients for whom both appetite and weight data were available from 4 prospective, 12- to 24-week clinical trials. Patients' appetites were assessed with Eating Behavior Assessment (EBA, Study 1), Platypus Appetite Rating Scale (PARS, Study 2), Eating Inventory (EI, Study 3), Food Craving Inventory (FCI, Study 3), and Eating Attitude Scale (EAS, Study 4).

Results

In Studies 1 (EBA) and 4 (EAS), patients who reported overall score increases on appetite scales, indicating an increase in appetite, experienced the greatest overall weight gains. However, in Studies 2 (PARS) and 3 (EI, FCI), patients who reported overall score increases on appetite scales did not experience greater weight changes than patients not reporting score increases. Early weight changes (2-4 weeks) were more positively correlated with overall weight changes than early or overall score changes on any utilized appetite assessment scale. No additional information was gained by adding early appetite change to early weight change in correlation to overall weight change.

Conclusions

Early weight changes may be a more useful predictor for long-term weight changes than early score changes on appetite assessment scales.

Clinical Trials Registration

This report represents secondary analyses of 4 clinical studies. Studies 1, 2, and 3 were registered at http://clinicaltrials.gov/ct2/home webcite, under NCT00190749, NCT00303602, and NCT00401973, respectively. Study 4 predates the registration requirements for observational studies that are not classified as category 1 observational studies.