Table 2

Study Schedule

< 48 h
 Day 4
 day 7
 day 14
 day 30
 5 months
 1 year
 2 year
Immune response







Response to immunizations




x
 x
Cytokine response
 x
x
 x
x
 x
Faecal Calprotectin/IL-8
 x
x
 x
 x
 x
 x
Postnatal adaptation of the gut







Intestinal permeability
 x
 x
 x




Intestinal microflora
 x
x
 x
 x
 x
 x
Intestinal viscosity



x
 x
 x
Long-term outcome







IgE/IgG4
 x



x
 x
Allergic and infectious diseases





x
Side effects immunizations†







Neurodevelopment





x
 x

†Standardized questionnaires (Preparedness and Response Unit, Centre for Infectious disease Control Netherlands, National Institute for Public Health and the Environment, The Netherlands) after the 1st, 2nd, 3rd and 4th immunization.

Westerbeek et al. BMC Pediatrics 2008 8:46   doi:10.1186/1471-2431-8-46