Table 5

Analysis of adverse effects of therapeutic hypothermia

Number of included trials

Number of participants

Adverse event

Relative risk (95% CI)


4 [10,11,21,25]

526

Sinus bradycardia

7.42 (2.52, 21.87)

Number needed to harm: 13 (95% CI: 8, 20)

3 [10,11,21]

464

Arrhythmia requiring treatment

1.04 (0.07, 16.39)

4 [10,11,21,24]

483

Hypotension

1.17 (0.96, 1.42)

3 [10,21,25]

318

Thrombocytopenia

1.47 (1.07, 2.03)

Number needed to harm: 8 (95% CI: 5, 50)

3 [10,11,25]

500

Coagulopathy

1.28 (0.94, 1.75)

2 [10,25]

292

Anemia

1.75 (0.86, 3.57)

3 [10,11,21]

464

Hypoglycemia

0.76 (0.49 to 1.17)

5 [10,11,21,24,25]

545

Abnormal renal function

0.91 (0.79 to 1.05)

2 [10,11]

448

Hepatic dysfunction

0.83 (0.64, 1.09)

4 [10,11,21,25]

526

Sepsis

1.04 (0.45 to 2.39)

5 [10,11,21,24,25]

545

Seizures

1.04 (0.91 to 1.18)

2 [10,25]

292

Hypokalemia

1.02 (0.84 to 1.25)


Schulzke et al. BMC Pediatrics 2007 7:30   doi:10.1186/1471-2431-7-30

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