Table 2

Inclusion criteria of included trials

Selective head cooling

Whole body cooling


Gunn 1998

Gluckman 2005

Shankaran 2002

Shankaran 2005

Eicher 2005


Definition of asphyxia

5 min Apgar < 7 or pH < 7,1 (first hour)

10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 mmol (first hour)

pH < 7.0 or BD > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*)

10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 16 or (if no blood gas or pH 7.01–7.15 or BD# 10–15 mmol: acute perinatal event and seizures or HIE*)

10 min Apgar < 6 or resuscitation or pH < 7.0 or BD# > 13 or acute perinatal event

Definition of HIE*

Sarnat stage 2–3

Pre-randomisation EEG and Sarnat stage 2–3

Modified Sarnat stage 2–3

Modified Sarnat stage 2–3

Sarnat stage 1–3


#BD base deficit * Hypoxic ischemic encephalopathy

Schulzke et al. BMC Pediatrics 2007 7:30   doi:10.1186/1471-2431-7-30

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