Table 1

Characteristics of included trials

Included trials

Selective head cooling

Whole body cooling


Gunn 1998

Gluckman 2005

Shankaran 2002

Shankaran 2005

Eicher 2005


Design

RCT

RCT

Multicenter

RCT

Multicenter

RCT

Multicenter

RCT

Multicenter

Number of participants

26

234

19

208

65

Gestation

≥ 37 wks

≥ 37 wks

≥ 36 wks

≥ 37 wks

≥ 35 wks

Inclusion criteria (details see Table 2)

Asphyxia and moderate to severe HIE

Asphyxia and moderate to severe HIE

Asphyxia and moderate to severe HIE

Asphyxia and moderate to severe HIE

Asphyxia and HIE

Target temperature treatment group (°C)

34.5–35.5 (n = 6)

34.0–35.0 (n = 7)

Not analyzed:

36.0–36.5 (n = 6)

35.5–35.9 (n = 6)

34.0–35.0

34.5

33.5

32.5–33.5

Target temperature control group (°C)

36.8–37.2

36.5–37.5

36.5

36.5–37.0

36.5–37.5

Site of temperature probe

Rectal

Rectal

Esophageal

Esophageal

Rectal

Average age at start of cooling (min)

294

330

318

302

120

Duration of cooling (h)

48–72

72

72

72

48

Cooling device

Servo-controlled cooling cap

Servo-controlled cooling cap

Two servo-controlled cooling blankets

Two servo-controlled cooling blankets

Ice bags followed by one servo-controlled cooling blanket

Primary outcome

Adverse events

Composite of death/severe disability

Adverse events

Composite of death/moderate or severe disability

Adverse events

Latest follow-up (months)

18

18

Follow-up not reported

18–22

12

Follow-up tools

Bayley II

Bayley II

GMF

-

Bayley II

GMF

Bayley II

Vineland


Schulzke et al. BMC Pediatrics 2007 7:30   doi:10.1186/1471-2431-7-30

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