Secondary outcome: neurodevelopmental disability at 18 to 22 months. Forest plot displays relative risk of neurodevelopmental disability at 18 to 22 months for all included studies and separately for selective head cooling and whole body cooling studies. There is a significant benefit of therapeutic hypothermia on the single outcome of neurodevelopmental disability at 18 to 22 months (RR: 0.72, 95% CI: 0.53, 0.98, NNT: 9, 95% CI: 5, 100). The squares represent the point estimate of treatment effect of each study with a horizontal line extending on either side of the square representing the 95% confidence interval. The arrowheads indicate a wide confidence interval that is compressed to fit the scale. The diamonds represent the overall and subgroup relative risk estimate of the studies presented in the meta-analysis. The widths of the diamonds represent the 95% confidence interval of the relative risk. The vertical midline of the forest plot corresponding to a relative risk of 1 represents a "no effect" line. Gunn et al 1998 and Gluckman et al 2005 assessed severe disability, Shankaran et al 2005 reported on moderate or severe disability as explained in the results.
Schulzke et al. BMC Pediatrics 2007 7:30 doi:10.1186/1471-2431-7-30